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    Prkd3 protein kinase D3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prkd3provided by RGD
    Official Full Name
    protein kinase D3provided by RGD
    Primary source
    RGD:1310236
    See related
    EnsemblRapid:ENSRNOG00000005289 AllianceGenome:RGD:1310236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prkcn
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 318.5), Lung (RPKM 232.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prkd3 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21784665..21860600)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16032507..16108444)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (1546018..1622232, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene glutaminyl-peptide cyclotransferase Neighboring gene ribosomal protein S17, pseudogene 9 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene CCAAT/enhancer binding protein zeta Neighboring gene CEBPZ opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors. Li C, et al. J Biol Chem, 2011 Nov 25. PMID 21971046, Free PMC Article
    2. Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD). Wang J, et al. J Biol Chem, 2016 Aug 19. PMID 27369082, Free PMC Article
    3. Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2. Lu G, et al. Cell Signal, 2007 Apr. PMID 17196367
    4. Protein kinase D regulates RhoA activity via rhotekin phosphorylation. Pusapati GV, et al. J Biol Chem, 2012 Mar 16. PMID 22228765, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. siRNA-mediated knockdown of PKD1, PKD2, and PKD3 markedly attenuated YAP nuclear-cytoplasmic shuttling, phosphorylation at Ser(127), and induction of Ctgf and Areg expression in response to GPCR activation.
      Title: Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).
    2. PKD3 is a pivotal mediator of the CaN-NFATc1/c3-PKD3-NFATc4 hypertrophic signaling cascade and a potential new drug target for the pathological cardiac hypertrophy
      Title: Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase D3
    Names
    protein kinase C, nu
    NP_001019434.2
    XP_006239691.1
    XP_006239693.1
    XP_038968056.1
    XP_038968057.1
    XP_063117874.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024263.2 → NP_001019434.2  serine/threonine-protein kinase D3

      See identical proteins and their annotated locations for NP_001019434.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6G5U2, D4A229
      Conserved Domains (4) summary
      cd01239
      Location:410 → 534
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:572 → 831
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:145 → 219
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:267 → 335
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      21784665..21860600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112129.2 → XP_038968057.1  serine/threonine-protein kinase D3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G5U2
      Related
      ENSRNOP00000079860.1, ENSRNOT00000095865.2
      Conserved Domains (4) summary
      cd01239
      Location:306 → 430
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:468 → 727
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:41 → 115
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:163 → 231
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    2. XM_039112128.2 → XP_038968056.1  serine/threonine-protein kinase D3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G5U2, D4A229
      Conserved Domains (4) summary
      cd01239
      Location:410 → 534
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:572 → 831
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:145 → 219
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:267 → 335
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    3. XM_006239629.5 → XP_006239691.1  serine/threonine-protein kinase D3 isoform X1

      See identical proteins and their annotated locations for XP_006239691.1

      UniProtKB/TrEMBL
      A0A8I6G5U2, D4A229
      Related
      ENSRNOP00000007491.4, ENSRNOT00000007492.9
      Conserved Domains (4) summary
      cd01239
      Location:410 → 534
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:572 → 831
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:145 → 219
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:267 → 335
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    4. XM_063261804.1 → XP_063117874.1  serine/threonine-protein kinase D3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G5U2, D4A229

    5. XM_006239631.5 → XP_006239693.1  serine/threonine-protein kinase D3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G5U2
      Conserved Domains (4) summary
      cd01239
      Location:306 → 430
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:468 → 727
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:41 → 115
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:163 → 231
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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