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    Ssrp1 structure specific recognition protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssrp1provided by RGD
    Official Full Name
    structure specific recognition protein 1provided by RGD
    Primary source
    RGD:621143
    See related
    EnsemblRapid:ENSRNOG00000008825 AllianceGenome:RGD:621143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in nucleosome disassembly and regulation of chromatin organization. Predicted to be located in nucleus. Predicted to be part of FACT complex. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 375.5), Spleen (RPKM 361.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ssrp1 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90531024..90541132)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (70124371..70134481)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72447516..72457621)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene proteoglycan 2, pro eosinophil major basic protein Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 Neighboring gene purinergic receptor P2X 3 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene apelin receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC. Charles Richard JL, et al. PLoS Genet, 2016 Jul. PMID 27467129, Free PMC Article
    2. Rat and chick cDNA clones encoding HMG-like proteins. Wang L, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464746, Free PMC Article
    3. The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization. Winkler DD, et al. J Biol Chem, 2011 May 27. PMID 21454601, Free PMC Article
    4. Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. Spencer JA, et al. J Biol Chem, 1999 May 28. PMID 10336466
    5. Inhibition of transcription by platinum antitumor compounds. Todd RC, et al. Metallomics, 2009. PMID 20046924, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94298

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in nucleosome disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FACT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FACT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of FACT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FACT complex subunit SSRP1
    Names
    T160
    facilitates chromatin transcription complex subunit SSRP1
    recombination signal sequence recognition protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031121.1 → NP_112383.1  FACT complex subunit SSRP1

      See identical proteins and their annotated locations for NP_112383.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083588
      UniProtKB/Swiss-Prot
      Q04931, Q5XIT2
      UniProtKB/TrEMBL
      A0A8L2R8I0, A6HMS9
      Conserved Domains (4) summary
      COG5165
      Location:21 → 480
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      cd13231
      Location:332 → 427
      PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
      pfam00505
      Location:547 → 614
      HMG_box; HMG (high mobility group) box
      pfam03531
      Location:75 → 284
      SSrecog; Structure-specific recognition protein (SSRP1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      90531024..90541132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761993.4 → XP_008760215.3  FACT complex subunit SSRP1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2R8I0
      Conserved Domains (2) summary
      COG5165
      Location:114 → 573
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      pfam00505
      Location:640 → 707
      HMG_box; HMG (high mobility group) box

    2. XM_063284636.1 → XP_063140706.1  FACT complex subunit SSRP1 isoform X1

      UniProtKB/Swiss-Prot
      Q04931, Q5XIT2
      UniProtKB/TrEMBL
      A0A8L2R8I0, A6HMS9

    3. XM_063284634.1 → XP_063140704.1  FACT complex subunit SSRP1 isoform X1

      UniProtKB/Swiss-Prot
      Q04931, Q5XIT2
      UniProtKB/TrEMBL
      A0A8L2R8I0, A6HMS9
      Related
      ENSRNOP00000073084.3, ENSRNOT00000091901.3

    4. XM_006234477.4 → XP_006234539.2  FACT complex subunit SSRP1 isoform X1

      UniProtKB/Swiss-Prot
      Q04931, Q5XIT2
      UniProtKB/TrEMBL
      A0A8L2R8I0, A6HMS9
      Related
      ENSRNOP00000012022.4, ENSRNOT00000012022.6
      Conserved Domains (4) summary
      COG5165
      Location:21 → 480
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      cd13231
      Location:332 → 427
      PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
      pfam00505
      Location:547 → 614
      HMG_box; HMG (high mobility group) box
      pfam03531
      Location:75 → 284
      SSrecog; Structure-specific recognition protein (SSRP1)

    5. XM_063284638.1 → XP_063140708.1  FACT complex subunit SSRP1 isoform X1

      UniProtKB/Swiss-Prot
      Q04931, Q5XIT2
      UniProtKB/TrEMBL
      A0A8L2R8I0, A6HMS9

    6. XM_063284635.1 → XP_063140705.1  FACT complex subunit SSRP1 isoform X1

      UniProtKB/Swiss-Prot
      Q04931, Q5XIT2
      UniProtKB/TrEMBL
      A0A8L2R8I0, A6HMS9

    7. XM_063284637.1 → XP_063140707.1  FACT complex subunit SSRP1 isoform X1

      UniProtKB/Swiss-Prot
      Q04931, Q5XIT2
      UniProtKB/TrEMBL
      A0A8L2R8I0, A6HMS9

    8. XM_063284633.1 → XP_063140703.1  FACT complex subunit SSRP1 isoform X1

      UniProtKB/Swiss-Prot
      Q04931, Q5XIT2
      UniProtKB/TrEMBL
      A0A8L2R8I0, A6HMS9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04931.2 GenPept UniProtKB/Swiss-Prot:Q04931

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