Cyp7b1 cytochrome P450 family 7 subfamily B member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp7b1provided by RGD
Official Full Name: cytochrome P450 family 7 subfamily B member 1provided by RGD
Primary source: RGD:2483
See related: EnsemblRapid:ENSRNOG00000009730 AllianceGenome:RGD:2483
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxysterol 7-alpha-hydroxylase activity. Involved in several processes, including circadian rhythm; memory; and response to cAMP. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 82.9), Kidney (RPKM 50.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (102419011..102586047, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (100502791..100669713, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (102701903..102871257, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

estrogen suppresses CYP7B1-catalyzed 7alpha-hydroxylation of DEHA
Title: Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis.
This study deminitrated that CYP7B1 mutations in patients with hereditary spastic paraplegia in French-Canadian.
Title: CYP7B1 mutations in French-Canadian hereditary spastic paraplegia subjects.
Abnormal expression of PPARalpha, CYP7B1 and ER may play a role in the pathogenesis of estrogen-induced intrahepatic cholestasis.
Title: [Interaction among peroxisome proliferators-activated receptor alpha, cytochrome P450 oxysterol 7α-hydroxylase and estrogen receptor and its association with intrahepatic cholestasis in pregnant rats].
Hepatic secretion of cholesterol and ABCG5/G8 expression are strongly stimulated in hypophysectomized rats during treatment with thyroid hormone.
Title: Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone.
CYP7B1 specific activity is highly regulated but does not seem to be rate limiting for bile acid synthesis.
Title: Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes.
Kidney CYP24 activity, possibly regulated by factors such as PTH, acts in concert with kidney CYP27B1 to control serum 1,25D levels.
Title: Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase- polymerase chain reaction.
in the rat CYP7B1 demonstrates diurnal rhythm and is regulated by bile acids and cholesterol
Title: Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat.

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General gene information

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Markers

AU049273 (e-PCR)
- UniSTS:145721

RH94670 (e-PCR)
- UniSTS:119917

D2Got54 (e-PCR)
- UniSTS:112507

ECD14651 (e-PCR)
- UniSTS:295671

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 25-hydroxycholesterol 7alpha-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxysterol 7-alpha-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxysterol 7-alpha-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables oxysterol 7-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables oxysterol 7-alpha-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxysterol 7-alpha-hydroxylase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in B cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in B cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in bile acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in memory	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in organic hydroxy compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in prostate gland epithelium morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostate gland epithelium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 25-hydroxycholesterol 7-alpha-hydroxylase

Names: HCT-1; cytochrome P450 7B1; cytochrome P450, family 7, subfamily b, polypeptide 1; cytochrome P450, subfamily 7B, polypeptide 1; hippocampal transcript 1 protein; oxysterol 7-alpha-hydroxylase

NP_062011.1

EC 1.14.14.29

XP_038957722.1

EC 1.14.14.29

XP_063137427.1

EC 1.14.14.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019138.1 → NP_062011.1 25-hydroxycholesterol 7-alpha-hydroxylase

Status: VALIDATED

Source sequence(s)

BF283070, CB749347, CB760136, CB800565, U36992

UniProtKB/TrEMBL

A6IHA6, G3V787

Related

ENSRNOP00000073111.2, ENSRNOT00000082084.3

Conserved Domains (1) summary

cl12078
Location:50 → 478

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

102419011..102586047 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101794.2 → XP_038957722.1 25-hydroxycholesterol 7-alpha-hydroxylase isoform X2

Conserved Domains (1) summary

cl41757
Location:67 → 351

cytochrome_P450; cytochrome P450 (CYP) superfamily
XM_063281357.1 → XP_063137427.1 25-hydroxycholesterol 7-alpha-hydroxylase isoform X1

UniProtKB/TrEMBL

A0A0G2K4N5