Cdc42se1 CDC42 small effector 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cdc42se1provided by RGD
Full Name: CDC42 small effector 1provided by RGD
Primary source: RGD:1561700
See related: EnsemblRapid:ENSRNOG00000060538 AllianceGenome:RGD:1561700
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in phagocytosis; regulation of Rho protein signal transduction; and regulation of cell shape. Predicted to be located in cell junction. Predicted to be active in plasma membrane. Orthologous to human CDC42SE1 (CDC42 small effector 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 269.8), Lung (RPKM 247.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (185494692..185502519)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (182805691..182813520)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (196402837..196410664)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH137564 (e-PCR)
- UniSTS:219651

RH142436 (e-PCR)
- UniSTS:231683

BI276816 (e-PCR)
- UniSTS:249906

BE095806 (e-PCR)
- UniSTS:243529

RH129274 (e-PCR)
- UniSTS:212581

MARC_16118-16119:1018032271:1 (e-PCR)
- UniSTS:267966

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CDC42 small effector protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039044.1 → NP_001034133.1 CDC42 small effector protein 1

See identical proteins and their annotated locations for NP_001034133.1

Status: PROVISIONAL

Source sequence(s)

BC091418

UniProtKB/Swiss-Prot

Q5BJM7

Related

ENSRNOP00000099731.1, ENSRNOT00000086849.3

Conserved Domains (1) summary

cl00113
Location:29 → 67

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...