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    Aplp1 amyloid beta precursor like protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aplp1provided by RGD
    Official Full Name
    amyloid beta precursor like protein 1provided by RGD
    Primary source
    RGD:69257
    See related
    EnsemblRapid:ENSRNOG00000020851 AllianceGenome:RGD:69257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561211; Aplp1_retired
    Summary
    Predicted to enable adrenergic receptor binding activity and identical protein binding activity. Predicted to be involved in cellular response to norepinephrine stimulus; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and nervous system development. Predicted to act upstream of or within several processes, including cytosolic mRNA polyadenylation; extracellular matrix organization; and regulation of translation. Predicted to be located in membrane; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human APLP1 (amyloid beta precursor like protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1626.4) and Kidney (RPKM 53.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aplp1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94824330..94834705, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85696880..85707215, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88897525..88908750, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane immune signaling adaptor Tyrobp Neighboring gene hematopoietic cell signal transducer Neighboring gene NFKB inhibitor delta Neighboring gene kirre like nephrin family adhesion molecule 2 Neighboring gene NPHS1 adhesion molecule, nephrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization. Xue Y, et al. Proc Natl Acad Sci U S A, 2011 Sep 27. PMID 21930949, Free PMC Article
    2. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Wasco W, et al. Proc Natl Acad Sci U S A, 1992 Nov 15. PMID 1279693, Free PMC Article
    3. Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase. Weber B, et al. Cell Signal, 2006 Oct. PMID 16531006
    4. APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression. Cousins SL, et al. J Neurochem, 2015 Jun. PMID 25683482
    5. Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Cao Q, et al. Mol Cell Biol, 2005 Dec. PMID 16314516, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-2A adrenergic receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-2A adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-2B adrenergic receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-2B adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-2C adrenergic receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-2C adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to norepinephrine stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytosolic mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within forebrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    amyloid beta precursor like protein 1
    Names
    amyloid beta (A4) precursor-like protein 1
    amyloid-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100802.2 → NP_001094272.1  amyloid beta precursor like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001094272.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      B1WBV6, F1LRS5
      Conserved Domains (5) summary
      smart00006
      Location:46 → 211
      A4_EXTRA; amyloid A4
      pfam02177
      Location:55 → 154
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:602 → 641
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:156 → 211
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:289 → 471
      APP_E2; E2 domain of amyloid precursor protein

    2. NM_001399814.1 → NP_001386743.1  amyloid beta precursor like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J9X4, F1LRS5
      Related
      ENSRNOP00000028297.6, ENSRNOT00000028297.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94824330..94834705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088308.2 → XP_038944236.1  amyloid beta precursor like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AD03, F1LRS5
      Related
      ENSRNOP00000092071.2, ENSRNOT00000106909.2
      Conserved Domains (3) summary
      smart00006
      Location:46 → 211
      A4_EXTRA; amyloid A4
      pfam12925
      Location:289 → 471
      APP_E2; E2 domain of amyloid precursor protein
      cl41775
      Location:569 → 653
      JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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