Hivep1 HIVEP zinc finger 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hivep1provided by RGD
Official Full Name: HIVEP zinc finger 1provided by RGD
Primary source: RGD:727847
See related: EnsemblRapid:ENSRNOG00000014460 AllianceGenome:RGD:727847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA binding activity. Predicted to be involved in BMP signaling pathway; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytosol; mitochondrion; and nuclear body. Predicted to be active in nucleus. Orthologous to human HIVEP1 (HIVEP zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 81.1), Lung (RPKM 63.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (22790855..22920359, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (22585016..22714517, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (22278103..22403362, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 40

Names: human immunodeficiency virus type I enhancer binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105751.2 → NP_001099221.2 zinc finger protein 40

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A6J757

Conserved Domains (4) summary

smart00355
Location:2100 → 2121

ZnF_C2H2; zinc finger

PHA03247
Location:2272 → 2662

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:409 → 429

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:2074 → 2094

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

22790855..22920359 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095309.2 → XP_038951237.1 zinc finger protein 40 isoform X1

UniProtKB/TrEMBL

A6J757

Conserved Domains (6) summary

PHA03247
Location:2273 → 2663

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:409 → 429

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:2075 → 2095

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:2073 → 2095

zf-C2H2; Zinc finger, C2H2 type

pfam12756
Location:2101 → 2166

zf-C2H2_2; C2H2 type zinc-finger (2 copies)

pfam13465
Location:422 → 446

zf-H2C2_2; Zinc-finger double domain
XM_039095308.1 → XP_038951236.1 zinc finger protein 40 isoform X1

UniProtKB/TrEMBL

A6J757

Conserved Domains (6) summary

PHA03247
Location:2273 → 2663

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:409 → 429

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:2075 → 2095

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:2073 → 2095

zf-C2H2; Zinc finger, C2H2 type

pfam12756
Location:2101 → 2166

zf-C2H2_2; C2H2 type zinc-finger (2 copies)

pfam13465
Location:422 → 446

zf-H2C2_2; Zinc-finger double domain
XM_039095310.1 → XP_038951238.1 zinc finger protein 40 isoform X1

UniProtKB/TrEMBL

A6J757

Related

ENSRNOP00000019389.8, ENSRNOT00000019389.9

Conserved Domains (6) summary

PHA03247
Location:2273 → 2663

PHA03247; large tegument protein UL36; Provisional

sd00017
Location:409 → 429

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:2075 → 2095

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:2073 → 2095

zf-C2H2; Zinc finger, C2H2 type

pfam12756
Location:2101 → 2166

zf-C2H2_2; C2H2 type zinc-finger (2 copies)

pfam13465
Location:422 → 446

zf-H2C2_2; Zinc-finger double domain
XM_063276029.1 → XP_063132099.1 zinc finger protein 40 isoform X2

UniProtKB/TrEMBL

A6J757, F1M9H4
XM_063276031.1 → XP_063132101.1 zinc finger protein 40 isoform X4
XM_063276030.1 → XP_063132100.1 zinc finger protein 40 isoform X3