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    Sdsl serine dehydratase-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sdslprovided by RGD
    Official Full Name
    serine dehydratase-likeprovided by RGD
    Primary source
    RGD:1309192
    See related
    EnsemblRapid:ENSRNOG00000001391 AllianceGenome:RGD:1309192
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TDH; Sdhl
    Summary
    Enables ammonia-lyase activity; glutamate racemase activity; and pyridoxal phosphate binding activity. Predicted to be involved in L-serine catabolic process; isoleucine biosynthetic process; and threonine catabolic process. Orthologous to human SDSL (serine dehydratase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 26.1), Testes (RPKM 13.6) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sdsl in Genome Data Viewer
    Location:
    12q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41760252..41770465)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (36099693..36109914)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41636994..41647205)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481191 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase Neighboring gene uncharacterized LOC120095980 Neighboring gene LIM homeobox 5 Neighboring gene RNA binding motif protein 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of an l-serine/l-threonine dehydratase with glutamate racemase activity in mammals. Katane M, et al. Biochem J, 2020 Nov 13. PMID 33079132
    2. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
    3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-serine ammonia-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-serine ammonia-lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamate racemase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables threonine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables threonine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine dehydratase-like
    Names
    L-serine deaminase
    L-serine dehydratase-like
    L-serine dehydratase/L-threonine deaminase
    L-threonine dehydratase
    glutamate racemase
    NP_001101806.1
    XP_038945528.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108336.1 → NP_001101806.1  serine dehydratase-like

      See identical proteins and their annotated locations for NP_001101806.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/Swiss-Prot
      A0A6N3IN21, D3ZHV7
      Related
      ENSRNOP00000001882.9, ENSRNOT00000001882.8
      Conserved Domains (1) summary
      cd06448
      Location:17 → 326
      L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41760252..41770465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089600.2 → XP_038945528.1  serine dehydratase-like isoform X1

      Conserved Domains (1) summary
      cl00342
      Location:22 → 276
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6N3IN21.1 GenPept UniProtKB/Swiss-Prot:A0A6N3IN21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials