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    Ilkap ILK associated serine/threonine phosphatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64538, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ilkapprovided by RGD
    Official Full Name
    ILK associated serine/threonine phosphataseprovided by RGD
    Primary source
    RGD:620128
    See related
    EnsemblRapid:ENSRNOG00000020115 AllianceGenome:RGD:620128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation and regulation of nuclear cell cycle DNA replication. Predicted to be located in cytoplasm. Orthologous to human ILKAP (ILK associated serine/threonine phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 121.1), Adrenal (RPKM 104.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ilkap in Genome Data Viewer
    Location:
    9q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99413981..99436262, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (91966440..91988791, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98514599..98536586, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 30 Neighboring gene erythroferrone Neighboring gene uncharacterized LOC100912214 Neighboring gene uncharacterized LOC134480412 Neighboring gene hes family bHLH transcription factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel mammalian PP2C isozyme. Tong Y, et al. J Biol Chem, 1998 Dec 25. PMID 9857069
    2. Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. Flajolet M, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14663150, Free PMC Article
    3. ILK, PINCH and parvin: the tIPP of integrin signalling. Legate KR, et al. Nat Rev Mol Cell Biol, 2006 Jan. PMID 16493410
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C
      Title: Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of nuclear cell cycle DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integrin-linked kinase-associated serine/threonine phosphatase 2C
    Names
    PP2Cdelta
    protein phosphatase 2C
    NP_072128.2
    XP_038940097.1
    XP_038940098.1
    XP_063123756.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022606.2 → NP_072128.2  integrin-linked kinase-associated serine/threonine phosphatase 2C

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q6P6U8, Q9Z1Z6
      UniProtKB/TrEMBL
      A0A0G2JSS1, A6JQR2
      Related
      ENSRNOP00000027295.4, ENSRNOT00000027295.7
      Conserved Domains (1) summary
      cd00143
      Location:108 → 390
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      99413981..99436262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084170.2 → XP_038940098.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

      UniProtKB/TrEMBL
      A6JQR3
      Conserved Domains (1) summary
      cd00143
      Location:1 → 270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. XM_039084169.2 → XP_038940097.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

      UniProtKB/TrEMBL
      A6JQR3
      Conserved Domains (1) summary
      cd00143
      Location:1 → 270
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    3. XM_063267686.1 → XP_063123756.1  integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X1

      UniProtKB/TrEMBL
      A0A8I6GBB0, A6JQR1
      Related
      ENSRNOP00000083940.1, ENSRNOT00000119384.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1Z6.1 GenPept UniProtKB/Swiss-Prot:Q9Z1Z6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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