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    Dab2 DAB adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79128, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dab2provided by RGD
    Official Full Name
    DAB adaptor protein 2provided by RGD
    Primary source
    RGD:621007
    See related
    EnsemblRapid:ENSRNOG00000028930 AllianceGenome:RGD:621007
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Doc2; Doc-2
    Summary
    Enables low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of signal transduction; and positive regulation of transport. Located in clathrin-coated vesicle membrane and perinuclear region of cytoplasm. Used to study myocardial infarction. Biomarker of metabolic acidosis and myocardial infarction. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1253.6), Adrenal (RPKM 322.9) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Dab2 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (57241947..57294893)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (55514692..55567476)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (55747353..55768848)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene high-mobility group box 1, pseudogene 16 Neighboring gene uncharacterized LOC120100732 Neighboring gene uncharacterized LOC120100733 Neighboring gene complement C9 Neighboring gene FYN binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding  
    enables SMAD binding  
    enables SMAD binding  
    enables cargo receptor activity  
    enables cargo receptor activity  
    enables cargo receptor activity  
    enables clathrin adaptor activity  
    enables clathrin adaptor activity  
    enables clathrin adaptor activity  
    enables clathrin binding  
    enables integrin binding  
    enables low-density lipoprotein particle receptor binding PubMed 
    enables phosphatidylinositol binding  
    enables phosphatidylinositol-4,5-bisphosphate binding  
    enables protein binding PubMed 
    Items 1 - 25 of 73
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in cell differentiation  
    acts_upstream_of_or_within cell morphogenesis  
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in clathrin coat assembly PubMed 
    involved_in clathrin coat assembly  
    acts_upstream_of extrinsic apoptotic signaling pathway  
    acts_upstream_of_or_within hematopoietic stem cell proliferation  
    acts_upstream_of_or_within in utero embryonic development  
    NOT involved_in integrin-mediated signaling pathway  
    involved_in leading edge cell differentiation  
    involved_in leading edge cell differentiation  
    involved_in myeloid cell differentiation  
    involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
    involved_in negative regulation of androgen receptor signaling pathway  
    involved_in negative regulation of androgen receptor signaling pathway  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of neuron projection development PubMed 
    involved_in negative regulation of protein localization to plasma membrane  
    involved_in negative regulation of protein localization to plasma membrane  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway  
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway  
    involved_in positive regulation of aldosterone biosynthetic process PubMed 
    involved_in positive regulation of aldosterone secretion PubMed 
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of clathrin-dependent endocytosis  
    involved_in positive regulation of clathrin-dependent endocytosis  
    involved_in positive regulation of early endosome to late endosome transport  
    involved_in positive regulation of early endosome to late endosome transport  
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of endocytosis PubMed 
    involved_in positive regulation of endocytosis  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of integrin-mediated signaling pathway  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of receptor internalization  
    involved_in positive regulation of receptor recycling  
    involved_in positive regulation of substrate adhesion-dependent cell spreading PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription elongation by RNA polymerase II  
    involved_in protein transport  
    involved_in receptor-mediated endocytosis  
    acts_upstream_of_or_within receptor-mediated endocytosis  
    involved_in regulation of Rho-dependent protein serine/threonine kinase activity PubMed 
    acts_upstream_of_or_within renal protein absorption  
    involved_in response to salt PubMed 
    involved_in response to steroid hormone PubMed 
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in vesicle-mediated transport  
    Items 1 - 25 of 73
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    part_of clathrin coat of coated pit  
    is_active_in clathrin-coated pit  
    located_in clathrin-coated pit  
    located_in clathrin-coated pit  
    located_in clathrin-coated vesicle  
    located_in clathrin-coated vesicle  
    located_in clathrin-coated vesicle membrane PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in fibrillar center  
    located_in fibrillar center  
    is_active_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    located_in perinuclear region of cytoplasm PubMed 
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    disabled homolog 2
    Names
    C9
    DAB2, clathrin adaptor protein
    adaptor molecule disabled-2
    differentially expressed in ovarian carcinoma 2
    disabled 2, mitogen-responsive phosphoprotein
    disabled homolog 2 mitogen-responsive phosphoprotein
    mitogen-responsive phosphoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024159.2NP_077073.1  disabled homolog 2

      See identical proteins and their annotated locations for NP_077073.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O55048, O55049, O55050, O55051, O88797, O88798, Q4QRA2
      UniProtKB/TrEMBL
      F1LMP9
      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      57241947..57294893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103192.2XP_038959120.1  disabled homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      O55048, O55049, O55050, O55051, O88797, O88798, Q4QRA2
      UniProtKB/TrEMBL
      F1LMP9
      Related
      ENSRNOP00000043878.5, ENSRNOT00000050655.7
      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    2. XM_039103193.2XP_038959121.1  disabled homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLG3, A6KGF1
      Related
      ENSRNOP00000085574.1, ENSRNOT00000107345.2
      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    3. XM_063282609.1XP_063138679.1  disabled homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLG3, A6KGF1
    4. XM_039103194.2XP_038959122.1  disabled homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A2J0, A0A8I6A5T4
      Related
      ENSRNOP00000085091.1, ENSRNOT00000096270.2
      Conserved Domains (1) summary
      cd01215
      Location:35171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
    5. XM_063282610.1XP_063138680.1  disabled homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A2J0, A0A8I6A5T4
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