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    Tesk2 testis associated actin remodelling kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tesk2provided by RGD
    Official Full Name
    testis associated actin remodelling kinase 2provided by RGD
    Primary source
    RGD:619984
    See related
    EnsemblRapid:ENSRNOG00000017282 AllianceGenome:RGD:619984
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including focal adhesion assembly; protein phosphorylation; and spermatogenesis. Located in nucleus. Orthologous to human TESK2 (testis associated actin remodelling kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 57.4), Kidney (RPKM 36.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tesk2 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135415352..135507226)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130178715..130270594)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135574172..135659842)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 1 Neighboring gene metabolism of cobalamin associated C Neighboring gene coiled-coil domain containing 163 Neighboring gene ribosomal protein S26 like 4 Neighboring gene target of EGR1, exonuclease Neighboring gene mutY DNA glycosylase Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. Røsok O, et al. Genomics, 1999 Oct 1. PMID 10512679
    2. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. Toshima J, et al. J Biol Chem, 2001 Aug 17. PMID 11418599
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity testis-specific protein kinase 2
    Names
    testicular protein kinase 2
    testis-specific kinase 2
    NP_596887.1
    XP_038965137.1
    XP_038965138.1
    XP_038965139.1
    XP_063143181.1
    XP_063143182.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133396.2 → NP_596887.1  dual specificity testis-specific protein kinase 2

      See identical proteins and their annotated locations for NP_596887.1

      Status: PROVISIONAL

      Source sequence(s)
      AB049402
      UniProtKB/Swiss-Prot
      A1A5M5, Q924U5
      UniProtKB/TrEMBL
      A0A8I6A1L1, A6JZ94
      Conserved Domains (1) summary
      cd14155
      Location:64 → 316
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135415352..135507226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109210.2 → XP_038965138.1  dual specificity testis-specific protein kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      A1A5M5, Q924U5
      UniProtKB/TrEMBL
      A0A8I6A1L1, A6JZ94
      Related
      ENSRNOP00000023416.3, ENSRNOT00000023416.6
      Conserved Domains (1) summary
      cd14155
      Location:64 → 316
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

    2. XM_039109209.2 → XP_038965137.1  dual specificity testis-specific protein kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      A1A5M5, Q924U5
      UniProtKB/TrEMBL
      A0A8I6A1L1, A6JZ94
      Conserved Domains (1) summary
      cd14155
      Location:64 → 316
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

    3. XM_063287111.1 → XP_063143181.1  dual specificity testis-specific protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A1L1

    4. XM_039109211.2 → XP_038965139.1  dual specificity testis-specific protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A1L1
      Conserved Domains (1) summary
      cd14155
      Location:32 → 276
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

    5. XM_063287112.1 → XP_063143182.1  dual specificity testis-specific protein kinase 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924U5.1 GenPept UniProtKB/Swiss-Prot:Q924U5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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