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    Vsnl1 visinin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24877, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vsnl1provided by RGD
    Official Full Name
    visinin-like 1provided by RGD
    Primary source
    RGD:3966
    See related
    EnsemblRapid:ENSRNOG00000005345 AllianceGenome:RGD:3966
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nvp1; Ratnvp1
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of signal transduction. Predicted to act upstream of or within negative regulation of insulin secretion; positive regulation of exocytosis; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cytosol and membrane. Orthologous to human VSNL1 (visinin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 978.7), Adrenal (RPKM 154.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Vsnl1 in Genome Data Viewer
    Location:
    6q15
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (39757721..39878556, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (34038641..34159479, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (37001360..37121969, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547959 Neighboring gene GEN1 Holliday junction 5' flap endonuclease Neighboring gene structural maintenance of chromosomes 6 Neighboring gene mitochondrial ribosomal protein S10, pseudogene 1 Neighboring gene RAD51 associated protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC105475

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    Component Evidence Code Pubs
    located_in cytosol  
    located_in membrane  

    General protein information

    Preferred Names
    visinin-like protein 1
    Names
    21 kDa CABP
    NVL-1
    NVP-1
    VILIP
    neural visinin-like protein 1
    neurocalcin alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012686.2NP_036818.2  visinin-like protein 1

      See identical proteins and their annotated locations for NP_036818.2

      Status: PROVISIONAL

      Source sequence(s)
      BC092197
      UniProtKB/TrEMBL
      Q56A29
      Related
      ENSRNOP00000007609.3, ENSRNOT00000007609.7
      Conserved Domains (2) summary
      COG5126
      Location:15181
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:65125
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      39757721..39878556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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