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    Nr2c2 nuclear receptor subfamily 2, group C, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50659, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nr2c2provided by RGD
    Official Full Name
    nuclear receptor subfamily 2, group C, member 2provided by RGD
    Primary source
    RGD:3201
    See related
    EnsemblRapid:ENSRNOG00000010536 AllianceGenome:RGD:3201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tr4
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Predicted to be involved in several processes, including p38MAPK cascade; positive regulation of myoblast differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within lipopolysaccharide-mediated signaling pathway; meiotic cell cycle; and spermatogenesis. Predicted to be located in nucleoplasm. Orthologous to human NR2C2 (nuclear receptor subfamily 2 group C member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 236.9), Brain (RPKM 235.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nr2c2 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (126167350..126223942)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124610216..124666813)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (124005287..124030349)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 3 open reading frame 20 Neighboring gene uncharacterized LOC102554857 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene uncharacterized LOC134486612 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene uncharacterized LOC103692187 Neighboring gene rabenosyn, RAB effector

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in cerebellum development  
    involved_in intracellular receptor signaling pathway  
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway  
    acts_upstream_of_or_within meiotic cell cycle  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in p38MAPK cascade  
    involved_in positive regulation of behavior  
    involved_in positive regulation of embryonic development  
    involved_in positive regulation of embryonic development  
    involved_in positive regulation of myoblast differentiation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within spermatogenesis  
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    nuclear receptor subfamily 2 group C member 2
    Names
    TR4 orphan receptor
    TR4-NS orphan receptor
    orphan nuclear receptor TR4
    orphan receptor TR4
    testicular receptor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017323.2NP_059019.2  nuclear receptor subfamily 2 group C member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P55094
      UniProtKB/TrEMBL
      A6IBC1, G3V7F5
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      126167350..126223942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108274.2XP_038964202.1  nuclear receptor subfamily 2 group C member 2 isoform X2

      UniProtKB/Swiss-Prot
      P55094
      UniProtKB/TrEMBL
      A6IBC1, G3V7F5
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    2. XM_039108276.2XP_038964204.1  nuclear receptor subfamily 2 group C member 2 isoform X2

      UniProtKB/Swiss-Prot
      P55094
      UniProtKB/TrEMBL
      A6IBC1, G3V7F5
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    3. XM_039108269.2XP_038964197.1  nuclear receptor subfamily 2 group C member 2 isoform X2

      UniProtKB/Swiss-Prot
      P55094
      UniProtKB/TrEMBL
      A6IBC1, G3V7F5
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    4. XM_039108266.2XP_038964194.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/Swiss-Prot
      P55094
      UniProtKB/TrEMBL
      A0A8I6AGK0, A6IBB9
      Related
      ENSRNOP00000014354.4, ENSRNOT00000014353.7
      Conserved Domains (2) summary
      cd06952
      Location:394615
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:145231
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    5. XM_039108275.2XP_038964203.1  nuclear receptor subfamily 2 group C member 2 isoform X2

      UniProtKB/Swiss-Prot
      P55094
      UniProtKB/TrEMBL
      A6IBC1, G3V7F5
      Related
      ENSRNOP00000091661.2, ENSRNOT00000106878.2
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    6. XM_039108273.1XP_038964201.1  nuclear receptor subfamily 2 group C member 2 isoform X2

      UniProtKB/Swiss-Prot
      P55094
      UniProtKB/TrEMBL
      A6IBC1, G3V7F5
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
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