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    Cwc15 CWC15 spliceosome-associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cwc15provided by RGD
    Official Full Name
    CWC15 spliceosome-associated proteinprovided by RGD
    Primary source
    RGD:1310669
    See related
    EnsemblRapid:ENSRNOG00000008490 AllianceGenome:RGD:1310669
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310669
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of Prp19 complex and U2-type catalytic step 2 spliceosome. Orthologous to human CWC15 (CWC15 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 232.0), Muscle (RPKM 215.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cwc15 in Genome Data Viewer
    Location:
    8q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (19586900..19597817)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (11305401..11316326)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (12994131..13004958)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 4D-like 2 Neighboring gene lysine demethylase 4D Neighboring gene angiomotin-like 1 Neighboring gene uncharacterized LOC134479993 Neighboring gene piwi-like RNA-mediated gene silencing 4 Neighboring gene sodium channel modifier 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular architecture of the human Prp19/CDC5L complex. Grote M, et al. Mol Cell Biol, 2010 May. PMID 20176811, Free PMC Article
    2. Splicing and beyond: the many faces of the Prp19 complex. Chanarat S, et al. Biochim Biophys Acta, 2013 Oct. PMID 23742842
    3. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Bertram K, et al. Nature, 2017 Feb 16. PMID 28076346
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109502

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    spliceosome-associated protein CWC15 homolog
    Names
    CWC15 spliceosome-associated protein homolog
    protein CWC15 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024987.1 → NP_001020158.1  spliceosome-associated protein CWC15 homolog

      See identical proteins and their annotated locations for NP_001020158.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091396
      UniProtKB/Swiss-Prot
      Q5BJP2
      UniProtKB/TrEMBL
      A6JN94, D3ZS22
      Related
      ENSRNOP00000011856.4, ENSRNOT00000011855.7
      Conserved Domains (1) summary
      pfam04889
      Location:1 → 228
      Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      19586900..19597817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242520.5 → XP_006242582.1  spliceosome-associated protein CWC15 homolog isoform X1

      See identical proteins and their annotated locations for XP_006242582.1

      UniProtKB/Swiss-Prot
      Q5BJP2
      UniProtKB/TrEMBL
      A6JN94, D3ZS22
      Conserved Domains (1) summary
      pfam04889
      Location:1 → 228
      Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein

    2. XM_039080985.2 → XP_038936913.1  spliceosome-associated protein CWC15 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5BJP2
      UniProtKB/TrEMBL
      A6JN94, D3ZS22
      Conserved Domains (1) summary
      pfam04889
      Location:1 → 228
      Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJP2.1 GenPept UniProtKB/Swiss-Prot:Q5BJP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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