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    Hjurp Holliday junction recognition protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316602, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hjurpprovided by RGD
    Official Full Name
    Holliday junction recognition proteinprovided by RGD
    Primary source
    RGD:1305846
    See related
    EnsemblRapid:ENSRNOG00000022911 AllianceGenome:RGD:1305846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305846
    Summary
    Predicted to enable histone binding activity and identical protein binding activity. Predicted to be involved in CENP-A containing chromatin assembly; chromosome segregation; and regulation of protein-containing complex assembly. Predicted to be located in cytosol; kinetochore; and nuclear lumen. Predicted to be active in chromosome, centromeric region. Orthologous to human HJURP (Holliday junction recognition protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 79.0), Spleen (RPKM 61.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hjurp in Genome Data Viewer
    Location:
    9q35
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96301183..96315587, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88853379..88867730, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95347739..95362228, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene peptidylprolyl isomerase D, pseudogene 21 Neighboring gene uncharacterized LOC108351971

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome deposition. Zasadzińska E, et al. EMBO J, 2013 Jul 31. PMID 23771058, Free PMC Article
    2. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Dunleavy EM, et al. Cell, 2009 May 1. PMID 19410545
    3. Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading. Kim IS, et al. Mol Cell, 2012 May 11. PMID 22516971
    4. Histone chaperones in nucleosome assembly and human disease. Burgess RJ, et al. Nat Struct Mol Biol, 2013 Jan. PMID 23288364, Free PMC Article
    5. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. Hu H, et al. Genes Dev, 2011 May 1. PMID 21478274, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CENP-A containing chromatin assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Holliday junction recognition protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191813.2 → NP_001178742.1  Holliday junction recognition protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4A1W1
      Conserved Domains (3) summary
      pfam10384
      Location:11 → 68
      Scm3; Centromere protein Scm3
      pfam12346
      Location:254 → 373
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:393 → 451
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      96301183..96315587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245393.5 → XP_006245455.1  Holliday junction recognition protein isoform X1

      UniProtKB/TrEMBL
      D4A1W1
      Related
      ENSRNOP00000040906.5, ENSRNOT00000051065.6
      Conserved Domains (3) summary
      pfam10384
      Location:11 → 68
      Scm3; Centromere protein Scm3
      pfam12346
      Location:259 → 378
      HJURP_mid; Holliday junction recognition protein-associated repeat
      pfam12347
      Location:398 → 456
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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