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    Spred3 sprouty-related, EVH1 domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spred3provided by RGD
    Official Full Name
    sprouty-related, EVH1 domain containing 3provided by RGD
    Primary source
    RGD:1311713
    See related
    EnsemblRapid:ENSRNOG00000051915 AllianceGenome:RGD:1311713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311713
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in negative regulation of cell differentiation and negative regulation of signal transduction. Predicted to act upstream of or within negative regulation of MAPK cascade. Predicted to be active in plasma membrane. Orthologous to human SPRED3 (sprouty related EVH1 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 37.9), Brain (RPKM 23.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spred3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93586259..93597692, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84458779..84470425, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88101213..88112719, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene ryanodine receptor 1 Neighboring gene RAS guanyl releasing protein 4 Neighboring gene family with sequence similarity 98, member C Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene gametogenetin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Kato R, et al. Biochem Biophys Res Commun, 2003 Mar 21. PMID 12646235
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables stem cell factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lens fiber cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sprouty-related, EVH1 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415863.1 → NP_001402792.1  sprouty-related, EVH1 domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A096MJ78, A0A0G2K3F4, A6J9N6, B2GV40
      Related
      ENSRNOP00000086038.2, ENSRNOT00000113063.2

    RNA

    1. NR_183230.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93586259..93597692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759145.4 → XP_008757367.2  sprouty-related, EVH1 domain-containing protein 3 isoform X1

      Related
      ENSRNOP00000105772.1, ENSRNOT00000144520.1

    2. XM_017589125.3 → XP_017444614.1  sprouty-related, EVH1 domain-containing protein 3 isoform X2

      Related
      ENSRNOP00000072614.2, ENSRNOT00000090615.3

    3. XM_039111582.2 → XP_038967510.1  sprouty-related, EVH1 domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K3F4, B2GV40
      Conserved Domains (3) summary
      PRK12323
      Location:126 → 229
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam05210
      Location:265 → 369
      Sprouty; Sprouty protein (Spry)
      cl17171
      Location:2 → 84
      PH-like; Pleckstrin homology-like domain

    4. XM_008759146.3 → XP_008757368.1  sprouty-related, EVH1 domain-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_008757368.1

      UniProtKB/TrEMBL
      A0A096MJ78, A0A0G2K3F4, A6J9N6, B2GV40
      Conserved Domains (2) summary
      cd10574
      Location:2 → 115
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:296 → 393
      Sprouty; Sprouty protein (Spry)

    5. XM_039111583.2 → XP_038967511.1  sprouty-related, EVH1 domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K3F4, B2GV40
      Related
      ENSRNOP00000098719.1, ENSRNOT00000138145.1
      Conserved Domains (3) summary
      PRK12323
      Location:126 → 229
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam05210
      Location:265 → 369
      Sprouty; Sprouty protein (Spry)
      cl17171
      Location:2 → 84
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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