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    Rxylt1 ribitol xylosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rxylt1provided by RGD
    Official Full Name
    ribitol xylosyltransferase 1provided by RGD
    Primary source
    RGD:1309356
    See related
    EnsemblRapid:ENSRNOG00000004421 AllianceGenome:RGD:1309356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem5
    Summary
    Predicted to enable ribitol beta-1,4-xylosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A10. Orthologous to human RXYLT1 (ribitol xylosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 85.3), Brain (RPKM 84.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rxylt1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (59656274..59668140, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (57770841..57782695, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (64329341..64341201, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sentrin-specific protease 2-like Neighboring gene sentrin-specific protease 2-like Neighboring gene transmembrane p24 trafficking protein 2, pseudogene 1 Neighboring gene vacuolar protein sorting 54 homolog (S. cerevisiae), pseudogene 1 Neighboring gene arginine vasopressin receptor 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan. Manya H, et al. J Biol Chem, 2016 Nov 18. PMID 27733679, Free PMC Article
    2. The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition. Praissman JL, et al. Elife, 2016 Apr 29. PMID 27130732, Free PMC Article
    3. The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation. Willer T, et al. Elife, 2014 Oct 3. PMID 25279699, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribitol beta-1,4-xylosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribitol beta-1,4-xylosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribitol-5-phosphate xylosyltransferase 1
    Names
    transmembrane protein 5
    NP_001019930.2
    XP_008763613.1
    XP_038934677.1
    XP_038934678.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024759.2 → NP_001019930.2  ribitol-5-phosphate xylosyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HQM9, F7EM09, Q4V8J9
      Related
      ENSRNOP00000006051.7, ENSRNOT00000006051.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      59656274..59668140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765391.4 → XP_008763613.1  ribitol-5-phosphate xylosyltransferase 1 isoform X1

    2. XM_039078749.2 → XP_038934677.1  ribitol-5-phosphate xylosyltransferase 1 isoform X2

    3. XM_039078750.2 → XP_038934678.1  ribitol-5-phosphate xylosyltransferase 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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