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    Trim66 tripartite motif-containing 66 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361623, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim66provided by RGD
    Official Full Name
    tripartite motif-containing 66provided by RGD
    Primary source
    RGD:1595847
    See related
    EnsemblRapid:ENSRNOG00000014373 AllianceGenome:RGD:1595847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity and identical protein binding activity. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in chromatin; chromocenter; and nucleus. Orthologous to human TRIM66 (tripartite motif containing 66). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 27.3), Brain (RPKM 20.7) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Trim66 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (172903771..172974475, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (163468944..163539633, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174062176..174132732, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 33 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC134483770 Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene ribosomal protein L27A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding  
    enables identical protein binding  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromocenter  
    located_in nucleus  

    General protein information

    Preferred Names
    tripartite motif-containing protein 66

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191839.3 → NP_001178768.1  tripartite motif-containing protein 66

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5YCM4, F1M6Z0
      Related
      ENSRNOP00000087298.2, ENSRNOT00000094445.2
      Conserved Domains (7) summary
      cd05502
      Location:1174 → 1282
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:213 → 338
      BBC; B-Box C-terminal domain
      cd00162
      Location:28 → 81
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19794
      Location:168 → 210
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:109 → 145
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl17238
      Location:27 → 82
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl22851
      Location:1101 → 1149
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      172903771..172974475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082572.2 → XP_038938500.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/TrEMBL
      A0A8I5YCM4, F1M6Z0
      Conserved Domains (7) summary
      cd05502
      Location:1174 → 1282
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:213 → 338
      BBC; B-Box C-terminal domain
      cd00162
      Location:28 → 81
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19794
      Location:168 → 210
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:109 → 145
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl17238
      Location:27 → 82
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl22851
      Location:1101 → 1149
      PHD_SF; PHD finger superfamily
    2. XM_006229983.5 → XP_006230045.1  tripartite motif-containing protein 66 isoform X6

      UniProtKB/TrEMBL
      A0A8I5YCM4
      Related
      ENSRNOP00000078067.2, ENSRNOT00000103681.2
      Conserved Domains (4) summary
      cd05502
      Location:1138 → 1246
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:177 → 302
      BBC; B-Box C-terminal domain
      pfam00643
      Location:133 → 168
      zf-B_box; B-box zinc finger
      cl22851
      Location:1065 → 1113
      PHD_SF; PHD finger superfamily
    3. XM_039082619.2 → XP_038938547.1  tripartite motif-containing protein 66 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GF03
      Conserved Domains (3) summary
      cd05502
      Location:980 → 1088
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:19 → 144
      BBC; B-Box C-terminal domain
      cd15625
      Location:907 → 955
      PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)
    4. XM_039082591.2 → XP_038938519.1  tripartite motif-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GF03
      Conserved Domains (5) summary
      cd05502
      Location:1069 → 1177
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd19794
      Location:63 → 105
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:4 → 40
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:996 → 1044
      PHD_SF; PHD finger superfamily
    5. XM_039082578.2 → XP_038938506.1  tripartite motif-containing protein 66 isoform X5

      UniProtKB/TrEMBL
      A0A8I5YCM4
      Conserved Domains (7) summary
      cd05502
      Location:1167 → 1275
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:206 → 331
      BBC; B-Box C-terminal domain
      cd00162
      Location:21 → 74
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19794
      Location:161 → 203
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:102 → 138
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl17238
      Location:20 → 75
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl22851
      Location:1094 → 1142
      PHD_SF; PHD finger superfamily
    6. XM_039082588.2 → XP_038938516.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A8I5YCM4
      Conserved Domains (7) summary
      cd05502
      Location:1001 → 1109
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:184 → 309
      BBC; B-Box C-terminal domain
      cd00162
      Location:2 → 52
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19794
      Location:139 → 181
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:80 → 116
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl17238
      Location:2 → 53
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl22851
      Location:928 → 976
      PHD_SF; PHD finger superfamily
    7. XM_039082562.2 → XP_038938490.1  tripartite motif-containing protein 66 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YCM4
      Conserved Domains (7) summary
      cd05502
      Location:1142 → 1250
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:184 → 309
      BBC; B-Box C-terminal domain
      cd00162
      Location:2 → 52
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19794
      Location:139 → 181
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:80 → 116
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl17238
      Location:2 → 53
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl22851
      Location:1069 → 1117
      PHD_SF; PHD finger superfamily
    8. XM_039082586.2 → XP_038938514.1  tripartite motif-containing protein 66 isoform X8

      UniProtKB/TrEMBL
      A0A8I5YCM4
      Conserved Domains (7) summary
      cd05502
      Location:1004 → 1112
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:184 → 309
      BBC; B-Box C-terminal domain
      cd00162
      Location:2 → 52
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19794
      Location:139 → 181
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:80 → 116
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl17238
      Location:2 → 53
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl22851
      Location:931 → 979
      PHD_SF; PHD finger superfamily
    9. XM_039082583.2 → XP_038938511.1  tripartite motif-containing protein 66 isoform X7

      UniProtKB/TrEMBL
      A0A8I5YCM4
      Conserved Domains (7) summary
      cd05502
      Location:1047 → 1155
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:184 → 309
      BBC; B-Box C-terminal domain
      cd00162
      Location:2 → 52
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19794
      Location:139 → 181
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:80 → 116
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl17238
      Location:2 → 53
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl22851
      Location:974 → 1022
      PHD_SF; PHD finger superfamily
    10. XM_039082602.2 → XP_038938530.1  tripartite motif-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GF03
      Conserved Domains (5) summary
      cd05502
      Location:1069 → 1177
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd19794
      Location:63 → 105
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:4 → 40
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:996 → 1044
      PHD_SF; PHD finger superfamily
    11. XM_017589382.3 → XP_017444871.1  tripartite motif-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GF03
      Conserved Domains (5) summary
      cd05502
      Location:1069 → 1177
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd19794
      Location:63 → 105
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:4 → 40
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:996 → 1044
      PHD_SF; PHD finger superfamily
    12. XM_017589380.3 → XP_017444869.1  tripartite motif-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GF03
      Conserved Domains (5) summary
      cd05502
      Location:1069 → 1177
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd19794
      Location:63 → 105
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:4 → 40
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:996 → 1044
      PHD_SF; PHD finger superfamily
    13. XM_039082626.2 → XP_038938554.1  tripartite motif-containing protein 66 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GF03
      Conserved Domains (3) summary
      cd05502
      Location:980 → 1088
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:19 → 144
      BBC; B-Box C-terminal domain
      cd15625
      Location:907 → 955
      PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)
    14. XM_039082621.2 → XP_038938549.1  tripartite motif-containing protein 66 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GF03
      Conserved Domains (3) summary
      cd05502
      Location:980 → 1088
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:19 → 144
      BBC; B-Box C-terminal domain
      cd15625
      Location:907 → 955
      PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)
    15. XM_039082623.2 → XP_038938551.1  tripartite motif-containing protein 66 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GF03
      Conserved Domains (3) summary
      cd05502
      Location:980 → 1088
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:19 → 144
      BBC; B-Box C-terminal domain
      cd15625
      Location:907 → 955
      PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)
    16. XM_017589379.3 → XP_017444868.1  tripartite motif-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GF03
      Conserved Domains (5) summary
      cd05502
      Location:1069 → 1177
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108 → 233
      BBC; B-Box C-terminal domain
      cd19794
      Location:63 → 105
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:4 → 40
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:996 → 1044
      PHD_SF; PHD finger superfamily
    17. XM_063267313.1 → XP_063123383.1  tripartite motif-containing protein 66 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GF03
    18. XM_039082564.2 → XP_038938492.1  tripartite motif-containing protein 66 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GF03
      Related
      ENSRNOP00000019368.6, ENSRNOT00000019368.9
      Conserved Domains (7) summary
      cd05502
      Location:1145 → 1253
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:184 → 309
      BBC; B-Box C-terminal domain
      cd00162
      Location:2 → 52
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19794
      Location:139 → 181
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:80 → 116
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl17238
      Location:2 → 53
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl22851
      Location:1072 → 1120
      PHD_SF; PHD finger superfamily
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