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    Aars2 alanyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301254, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aars2provided by RGD
    Official Full Name
    alanyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1310617
    See related
    EnsemblRapid:ENSRNOG00000025808 AllianceGenome:RGD:1310617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aarsl; AlaRS
    Summary
    Predicted to enable alanine-tRNA ligase activity and aminoacyl-tRNA editing activity. Predicted to be involved in mitochondrial alanyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 8 and progressive leukoencephalopathy with ovarian failure. Orthologous to human AARS2 (alanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 45.8), Heart (RPKM 40.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aars2 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22981880..22993536, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (15484639..15496116, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17869301..17881762, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor epsilon Neighboring gene transmembrane protein 151B Neighboring gene t-complex-associated testis expressed 1 Neighboring gene uncharacterized LOC108351892 Neighboring gene spermatogenesis associated, serine-rich 1 Neighboring gene cell division cycle 5-like Neighboring gene uncharacterized LOC108351893

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathy. Götz A, et al. Am J Hum Genet, 2011 May 13. PMID 21549344, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alanine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA editing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide lactyltransferase (ATP-dependent) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide lactyltransferase (ATP-dependent) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial alanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial alanyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alanine--tRNA ligase, mitochondrial
    Names
    alanyl-tRNA synthetase 2, mitochondrial (putative)
    alanyl-tRNA synthetase like
    alanyl-tRNA synthetase, mitochondrial
    probable alanyl-tRNA synthetase, mitochondrial
    XP_006244575.1
    XP_006244577.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431966.1 → NP_001418895.1  alanine--tRNA ligase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      D3ZX08

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22981880..22993536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244515.5 → XP_006244577.1  alanine--tRNA ligase, mitochondrial isoform X2

      Related
      ENSRNOP00000090578.3, ENSRNOT00000094858.3
      Conserved Domains (4) summary
      smart00863
      Location:740 → 773
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      PLN02900
      Location:34 → 978
      PLN02900; alanyl-tRNA synthetase
      cd00673
      Location:37 → 275
      AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cl08469
      Location:549 → 651
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

    2. XM_006244513.5 → XP_006244575.1  alanine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      D3ZX08
      Related
      ENSRNOP00000104177.1, ENSRNOT00000165288.1
      Conserved Domains (4) summary
      smart00863
      Location:740 → 773
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      PLN02900
      Location:34 → 1055
      PLN02900; alanyl-tRNA synthetase
      cd00673
      Location:37 → 275
      AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cl08469
      Location:549 → 651
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106891.1: Suppressed sequence

      Description
      NM_001106891.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZX08.1 GenPept UniProtKB/Swiss-Prot:D3ZX08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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