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    Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315167, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndufa6provided by RGD
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A6provided by RGD
    Primary source
    RGD:1309818
    See related
    EnsemblRapid:ENSRNOG00000008569 AllianceGenome:RGD:1309818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly and response to oxidative stress. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 33. Orthologous to human NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 2009.5), Muscle (RPKM 1394.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ndufa6 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115746460..115750317, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113866382..113870239, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123583062..123586919, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479948 Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene single-pass membrane protein with aspartate-rich tail 1 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 4 Neighboring gene uncharacterized LOC103692951 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in mitochondrial inner membrane  
    located_in mitochondrial membrane  
    located_in mitochondrion PubMed 
    part_of respiratory chain complex I  
    part_of respiratory chain complex I  

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130505.1NP_001123977.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

      See identical proteins and their annotated locations for NP_001123977.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HT69, D4A3V2
      Related
      ENSRNOP00000011484.3, ENSRNOT00000011484.6
      Conserved Domains (1) summary
      pfam13232
      Location:3294
      Complex1_LYR_1; Complex1_LYR-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115746460..115750317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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