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    Pde8b phosphodiesterase 8B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pde8bprovided by RGD
    Official Full Name
    phosphodiesterase 8Bprovided by RGD
    Primary source
    RGD:735041
    See related
    EnsemblRapid:ENSRNOG00000010280 AllianceGenome:RGD:735041
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RNPDE8B
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 3. Orthologous to human PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 104.4), Brain (RPKM 87.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde8b in Genome Data Viewer
    Location:
    2q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (28009841..28244050, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (26275117..26479725, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (24718548..24955533, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350223 Neighboring gene WD repeat domain 41 Neighboring gene uncharacterized LOC134485577 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134485576 Neighboring gene uncharacterized LOC134485713 Neighboring gene uncharacterized LOC100912266 Neighboring gene succinate dehydrogenase complex subunit C, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose. Dov A, et al. Endocrinology, 2008 Feb. PMID 17991719
    2. Molecular comparison of rat cyclic nucleotide phosphodiesterase 8 family: unique expression of PDE8B in rat brain. Kobayashi T, et al. Gene, 2003 Nov 13. PMID 14597168
    3. Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase. Hayashi M, et al. Biochem Biophys Res Commun, 1998 Sep 29. PMID 9784418
    4. The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Tsai LC, et al. Mol Pharmacol, 2011 Apr. PMID 21187369, Free PMC Article
    5. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Waddleton D, et al. Biochem Pharmacol, 2008 Oct 1. PMID 18706893

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of steroid hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within operant conditioning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
    Names
    cAMP-specific cyclic nucleotide phosphodiesterase PDE8
    NP_954889.1
    XP_006231873.1
    XP_008758892.1
    XP_017446305.1
    XP_017446306.1
    XP_038958091.1
    XP_038958092.1
    XP_063137771.1
    XP_063137772.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199268.2 → NP_954889.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

      See identical proteins and their annotated locations for NP_954889.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      F7ES56, Q76KC5
      Related
      ENSRNOP00000050643.4, ENSRNOT00000044087.5
      Conserved Domains (3) summary
      cd00130
      Location:160 → 252
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:490 → 737
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:155 → 253
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      28009841..28244050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281702.1 → XP_063137772.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

      UniProtKB/TrEMBL
      F7ES56

    2. XM_008760670.4 → XP_008758892.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTX5, A0A8I6GB63
      Related
      ENSRNOP00000082132.1, ENSRNOT00000112845.2
      Conserved Domains (4) summary
      cd00130
      Location:284 → 376
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:614 → 861
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase
      pfam13426
      Location:279 → 377
      PAS_9; PAS domain

    3. XM_063281701.1 → XP_063137771.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

      UniProtKB/TrEMBL
      A0A8I6AKA5

    4. XM_017590817.3 → XP_017446306.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3

      UniProtKB/TrEMBL
      A0A8I6AKA5
      Related
      ENSRNOP00000089849.2, ENSRNOT00000115022.2

    5. XM_039102163.2 → XP_038958091.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

      UniProtKB/TrEMBL
      A0A8I6AKA5, A6I4Y1
      Conserved Domains (3) summary
      PHA02597
      Location:157 → 310
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:516 → 763
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase

    6. XM_006231811.5 → XP_006231873.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

      UniProtKB/TrEMBL
      A0A8I6AJW4, A0A8I6AKA5
      Related
      ENSRNOP00000093463.1, ENSRNOT00000116408.2
      Conserved Domains (3) summary
      PHA02597
      Location:158 → 311
      30.2; hypothetical protein; Provisional
      pfam00233
      Location:517 → 764
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08629
      Location:1 → 47
      PDE8; PDE8 phosphodiesterase

    7. XM_017590816.3 → XP_017446305.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

      UniProtKB/TrEMBL
      A0A8I6GB63

    8. XM_039102164.2 → XP_038958092.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZT43
      Conserved Domains (3) summary
      COG2202
      Location:55 → 263
      PAS; PAS domain [Signal transduction mechanisms]
      pfam00233
      Location:502 → 749
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:168 → 265
      PAS_9; PAS domain
    Nucleotide Protein Strain
    Heading Accession and Version

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