Tmem182 transmembrane protein 182 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem182provided by RGD
Official Full Name: transmembrane protein 182provided by RGD
Primary source: RGD:1563696
See related: EnsemblRapid:ENSRNOG00000028945 AllianceGenome:RGD:1563696
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563696
Summary: Predicted to be involved in myotube cell development involved in skeletal muscle regeneration; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Predicted to be located in plasma membrane. Orthologous to human TMEM182 (transmembrane protein 182). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 857.4), Muscle (RPKM 807.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (50555029..50606908)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (43059432..43111318)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (47536824..47588677)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in myotube cell development involved in skeletal muscle regeneration	ISO Inferred from Sequence Orthology more info
involved_in myotube differentiation involved in skeletal muscle regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 182

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109305.1 → NP_001102775.1 transmembrane protein 182

See identical proteins and their annotated locations for NP_001102775.1

Status: PROVISIONAL

Source sequence(s)

CH473965

UniProtKB/TrEMBL

A6INP7

Related

ENSRNOP00000049496.5, ENSRNOT00000049349.5

Conserved Domains (1) summary

pfam13903
Location:15 → 220

Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

50555029..50606908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084079.1 → XP_038940007.1 transmembrane protein 182 isoform X2

UniProtKB/TrEMBL

D3ZZT3

Conserved Domains (1) summary

cl21598
Location:13 → 167

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
XM_039084081.2 → XP_038940009.1 transmembrane protein 182 isoform X4

Conserved Domains (1) summary

cl21598
Location:15 → 110

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
XM_039084077.1 → XP_038940005.1 transmembrane protein 182 isoform X1

Conserved Domains (1) summary

cl21598
Location:15 → 174

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
XM_039084078.2 → XP_038940006.1 transmembrane protein 182 isoform X2

UniProtKB/TrEMBL

D3ZZT3

Conserved Domains (1) summary

cl21598
Location:13 → 167

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
XM_039084080.2 → XP_038940008.1 transmembrane protein 182 isoform X3

Conserved Domains (1) summary

cl21598
Location:58 → 121

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family