Krt71 keratin 71 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt71provided by RGD
Official Full Name: keratin 71provided by RGD
Primary source: RGD:1584538
See related: EnsemblRapid:ENSRNOG00000049495 AllianceGenome:RGD:1584538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in hair follicle morphogenesis; intermediate filament organization; and keratinization. Predicted to be active in keratin filament. Used to study alopecia. Human ortholog(s) of this gene implicated in hypotrichosis 13. Orthologous to human KRT71 (keratin 71). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 47.9), Brain (RPKM 10.7) and 3 other tissues See more
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Genomic context

Location:: 7q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (134752240..134778765, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (132873532..132898975, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (143345201..143371346, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a 7-bp deletion at the splicing acceptor site of intron 1 of the keratin 71 (Krt71) gene plays an important role in hair formation.
Title: Identification of the rat Rex mutation as a 7-bp deletion at splicing acceptor site of the Krt71 gene.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin 71

Names: keratin 71, type II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276440.1 → NP_001263369.1 keratin 71

See identical proteins and their annotated locations for NP_001263369.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6KCR3, U3R784, U3R7A7, U5LJQ0

Related

ENSRNOP00000059953.3, ENSRNOT00000068533.5

Conserved Domains (2) summary

pfam00038
Location:130 → 443

Filament; Intermediate filament protein

pfam16208
Location:15 → 127

Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

134752240..134778765 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079885.2 → XP_038935813.1 keratin 71 isoform X1

UniProtKB/TrEMBL

A6KCR3, U3R784, U3R7A7, U5LJQ0

Conserved Domains (2) summary

pfam00038
Location:130 → 443

Filament; Intermediate filament protein

pfam16208
Location:15 → 127

Keratin_2_head; Keratin type II head