Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamts16provided by RGD
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 16provided by RGD
Primary source: RGD:1310046
See related: EnsemblRapid:ENSRNOG00000016812 AllianceGenome:RGD:1310046
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metalloendopeptidase activity. Involved in male gamete generation; regulation of cilium assembly; and regulation of systemic arterial blood pressure. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Used to study cryptorchidism; hypertension; and male infertility. Orthologous to human ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 38.6), Muscle (RPKM 6.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (34258899..34388952)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (32430436..32562481)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (35067268..35200530)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interplay between collagenase and undescended testes in Adamts16 knockout rats.
Title: Interplay between collagenase and undescended testes in Adamts16 knockout rats.
These observations, taken together with our previous report of renal abnormalities observed with the same Adamts16mutant rats, suggest an important mechanistic link between Adamts16 and the functioning of the male genitourinary system.
Title: Cryptorchidism and infertility in rats with targeted disruption of the Adamts16 locus.
physiological observations functionally link Adamts16 to blood pressure regulation and suggest the vasculature as the potential site of action of Adamts16 to lower blood pressure
Title: Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.
Genetic variation of Adamts16 is linked to inherited hypertension in a rat model.
Title: Positional identification of variants of Adamts16 linked to inherited hypertension.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Mco109 (e-PCR)
- UniSTS:527712

D1Mco110 (e-PCR)
- UniSTS:527717

D1Mco108 (e-PCR)
- UniSTS:527726

D1Mco111 (e-PCR)
- UniSTS:527727

D1Mco106 (e-PCR)
- UniSTS:527733

D1Mco107 (e-PCR)
- UniSTS:527738

AU028973 (e-PCR)
- UniSTS:111815

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 16

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372015.3 → NP_001358944.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D3ZLL7

Related

ENSRNOP00000022790.7, ENSRNOT00000022790.10

Conserved Domains (6) summary

smart00209
Location:586 → 638

TSP1; Thrombospondin type 1 repeats

cd04273
Location:287 → 488

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:57 → 202

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:745 → 855

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1187 → 1217

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:505 → 572

ADAM_CR_2; ADAM cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

34258899..34388952

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110074.2 → XP_038966002.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X2

Conserved Domains (6) summary

smart00209
Location:586 → 638

TSP1; Thrombospondin type 1 repeats

cd04273
Location:287 → 488

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:745 → 855

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:74 → 202

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:505 → 572

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:876 → 924

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_039110071.2 → XP_038965999.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X1

Conserved Domains (6) summary

smart00209
Location:356 → 408

TSP1; Thrombospondin type 1 repeats

cd04273
Location:57 → 258

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:515 → 625

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:957 → 987

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:275 → 342

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:757 → 814

TSP1_ADAMTS; Thrombospondin type 1 domain
XM_063288087.1 → XP_063144157.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X3

UniProtKB/TrEMBL

A6JUZ7

RNA

XR_005504458.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107332.1: Suppressed sequence

Description

NM_001107332.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: ADAMTS16 (GeneID:170690).