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    Pik3ip1 phosphoinositide-3-kinase interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305472, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pik3ip1provided by RGD
    Official Full Name
    phosphoinositide-3-kinase interacting protein 1provided by RGD
    Primary source
    RGD:1311203
    See related
    EnsemblRapid:ENSRNOG00000018859 AllianceGenome:RGD:1311203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    zgc:66482; RGD1311203
    Summary
    Predicted to enable endopeptidase activity; phosphatidylinositol 3-kinase inhibitor activity; and signaling receptor binding activity. Predicted to be involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human PIK3IP1 (phosphoinositide-3-kinase interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 185.5), Muscle (RPKM 130.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Pik3ip1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82428315..82440261)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78204668..78216616)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83559397..83572481)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene LIM domain kinase 2 Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein L7, pseudogene 1 Neighboring gene ring finger protein 185 Neighboring gene uncharacterized LOC134481864

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity  
    enables phosphatidylinositol 3-kinase inhibitor activity  
    enables phosphatidylinositol 3-kinase inhibitor activity  
    enables phosphatidylinositol 3-kinase inhibitor activity  
    enables signaling receptor binding  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in plasma membrane  

    General protein information

    Preferred Names
    phosphoinositide-3-kinase-interacting protein 1
    Names
    HGFL protein
    kringle domain-containing protein HGFL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395158.1NP_001382087.1  phosphoinositide-3-kinase-interacting protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q56A20
      UniProtKB/TrEMBL
      A6IK99, G3V9P1
      Related
      ENSRNOP00000095057.2, ENSRNOT00000112805.2
      Conserved Domains (1) summary
      smart00130
      Location:23103
      KR; Kringle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      82428315..82440261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092006.2XP_038947934.1  phosphoinositide-3-kinase-interacting protein 1 isoform X1

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