U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rcor3 REST corepressor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684192, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Symbol
    Rcor3provided by RGD
    Full Name
    REST corepressor 3provided by RGD
    Primary source
    RGD:1593864
    See related
    EnsemblRapid:ENSRNOG00000046445 AllianceGenome:RGD:1593864
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Orthologous to human RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 61.0), Lung (RPKM 55.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rcor3 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (106156166..106196542, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (103624966..103665565, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (110822149..110864469, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene RD3 regulator of GUCY2D Neighboring gene TNF receptor-associated factor 5 Neighboring gene uncharacterized LOC102546453 Neighboring gene 40S ribosomal protein S19-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation. Upadhyay G, et al. Proc Natl Acad Sci U S A, 2014 Jun 3. PMID 24843136, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC189413

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    REST corepressor 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134985.1 → NP_001128457.1  REST corepressor 3

      See identical proteins and their annotated locations for NP_001128457.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169033
      UniProtKB/TrEMBL
      A6JH09, B5DFE7, M0R4M7
      Related
      ENSRNOP00000077639.2, ENSRNOT00000117569.2
      Conserved Domains (4) summary
      smart00717
      Location:345 → 390
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:345 → 388
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:57 → 108
      ELM2; ELM2 domain
      cl21498
      Location:144 → 188
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      106156166..106196542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091094.2 → XP_038947022.1  REST corepressor 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZS59
      Related
      ENSRNOP00000080003.1, ENSRNOT00000102506.2
      Conserved Domains (2) summary
      pfam01448
      Location:57 → 108
      ELM2; ELM2 domain
      cl21498
      Location:144 → 188
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    2. XM_039091095.2 → XP_038947023.1  REST corepressor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YCF9
      Related
      ENSRNOP00000089815.2, ENSRNOT00000110034.2
      Conserved Domains (2) summary
      pfam01448
      Location:57 → 108
      ELM2; ELM2 domain
      cl21498
      Location:144 → 188
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    3. XM_039091096.2 → XP_038947024.1  REST corepressor 3 isoform X3

      UniProtKB/TrEMBL
      A6JH09
      Conserved Domains (2) summary
      pfam00249
      Location:226 → 269
      Myb_DNA-binding; Myb-like DNA-binding domain
      cl21498
      Location:25 → 69
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    4. XM_039091098.2 → XP_038947026.1  REST corepressor 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AB49
      Related
      ENSRNOP00000064314.3, ENSRNOT00000073588.4
      Conserved Domains (2) summary
      pfam01448
      Location:57 → 108
      ELM2; ELM2 domain
      cl21498
      Location:144 → 188
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RNA

    1. XR_005492289.2 RNA Sequence

    2. XR_005492288.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools