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    Zbtb22 zinc finger and BTB domain containing 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb22provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 22provided by RGD
    Primary source
    RGD:1359627
    See related
    EnsemblRapid:ENSRNOG00000000476 AllianceGenome:RGD:1359627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bing1; Zfp297; Znf297
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZBTB22 (zinc finger and BTB domain containing 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 62.3), Heart (RPKM 60.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb22 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4968215..4971734, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4966331..4969853, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5476345..5479900, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator like 2 Neighboring gene TAP binding protein Neighboring gene death-domain associated protein Neighboring gene AA926063gene Neighboring gene small integral membrane protein 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 22
    Names
    zinc finger protein 297

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009172.3 → NP_001009172.1  zinc finger and BTB domain-containing protein 22

      See identical proteins and their annotated locations for NP_001009172.1

      Status: VALIDATED

      Source sequence(s)
      BC095905
      UniProtKB/TrEMBL
      A0A8I6A8H9, A6JJI6, Q6MGC7
      Related
      ENSRNOP00000098206.1, ENSRNOT00000120565.2
      Conserved Domains (4) summary
      sd00017
      Location:485 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18210
      Location:36 → 147
      BTB_POZ_ZBTB22_BING1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22)
      pfam00096
      Location:510 → 532
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:524 → 547
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4968215..4971734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256123.5 → XP_006256185.1  zinc finger and BTB domain-containing protein 22 isoform X1

      See identical proteins and their annotated locations for XP_006256185.1

      UniProtKB/TrEMBL
      A0A8I6A8H9, A6JJI6, Q6MGC7
      Conserved Domains (4) summary
      sd00017
      Location:485 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18210
      Location:36 → 147
      BTB_POZ_ZBTB22_BING1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22)
      pfam00096
      Location:510 → 532
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:524 → 547
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017601641.3 → XP_017457130.1  zinc finger and BTB domain-containing protein 22 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8H9, A6JJI6, Q6MGC7
      Conserved Domains (4) summary
      sd00017
      Location:485 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18210
      Location:36 → 147
      BTB_POZ_ZBTB22_BING1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22)
      pfam00096
      Location:510 → 532
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:524 → 547
      zf-H2C2_2; Zinc-finger double domain

    3. XM_039098679.2 → XP_038954607.1  zinc finger and BTB domain-containing protein 22 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8H9, A6JJI6, Q6MGC7
      Conserved Domains (4) summary
      sd00017
      Location:485 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18210
      Location:36 → 147
      BTB_POZ_ZBTB22_BING1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22)
      pfam00096
      Location:510 → 532
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:524 → 547
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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