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    Txnrd2 thioredoxin reductase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50551, updated on 9-Dec-2024

    Summary

    Official Symbol
    Txnrd2provided by RGD
    Official Full Name
    thioredoxin reductase 2provided by RGD
    Primary source
    RGD:61960
    See related
    EnsemblRapid:ENSRNOG00000001890 AllianceGenome:RGD:61960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tr3; Trxr2; Trxrd2
    Summary
    The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2017]
    Expression
    Biased expression in Adrenal (RPKM 156.2), Heart (RPKM 114.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Txnrd2 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96024321..96072475, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82519996..82568156, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86667994..86716063, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 1 Neighboring gene G protein subunit beta 1 like Neighboring gene uncharacterized LOC120095703 Neighboring gene catechol-O-methyltransferase Neighboring gene ARVCF, delta catenin family member Neighboring gene small Cajal body-specific RNA 14 like 2 Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA 185

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93435

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell redox homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to hydrogen peroxide TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxygen radical TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to selenium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    thioredoxin reductase 2, mitochondrial
    Names
    thioredoxin reductase TR3
    NP_072106.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022584.3NP_072106.1  thioredoxin reductase 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_072106.1

      Status: REVIEWED

      Source sequence(s)
      BC085734, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q9Z0J5
      UniProtKB/TrEMBL
      A6JSG3
      Related
      ENSRNOP00000002593.7, ENSRNOT00000002593.9
      Conserved Domains (5) summary
      TIGR01438
      Location:41526
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:222288
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:398507
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl14785
      Location:126192
      FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains
      cl21454
      Location:4277
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96024321..96072475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)