Tmigd1 transmembrane and immunoglobulin domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmigd1provided by RGD
Official Full Name: transmembrane and immunoglobulin domain containing 1provided by RGD
Primary source: RGD:1307444
See related: EnsemblRapid:ENSRNOG00000003865 AllianceGenome:RGD:1307444
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmigd; RGD1307444
Summary: Predicted to enable cell-cell adhesion mediator activity and protein homodimerization activity. Predicted to be involved in several processes, including cell-cell adhesion; negative regulation of apoptotic process; and regulation of membrane permeability. Predicted to act upstream of or within several processes, including brush border assembly; cellular response to hydroperoxide; and intestinal epithelial cell maturation. Predicted to be located in cytosol; mitochondrion; and plasma membrane. Predicted to be active in cell surface and neuron projection. Orthologous to human TMIGD1 (transmembrane and immunoglobulin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 254.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (62234764..62249169)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (61739071..61751025)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (63262554..63274598, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brush border assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to hydroperoxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intestinal epithelial cell maturation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to nutrient	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane and immunoglobulin domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135029.1 → NP_001128501.1 transmembrane and immunoglobulin domain-containing protein 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

D3ZD96

Related

ENSRNOP00000005129.6, ENSRNOT00000005129.7

Conserved Domains (2) summary

smart00410
Location:130 → 211

IG_like; Immunoglobulin like

cd00096
Location:138 → 142

Ig; Ig strand B [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

62234764..62249169

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269523.1 → XP_063125593.1 transmembrane and immunoglobulin domain-containing protein 1 isoform X1
XM_063269525.1 → XP_063125595.1 transmembrane and immunoglobulin domain-containing protein 1 isoform X2
XM_063269524.1 → XP_063125594.1 transmembrane and immunoglobulin domain-containing protein 1 isoform X1
XM_063269526.1 → XP_063125596.1 transmembrane and immunoglobulin domain-containing protein 1 isoform X2