U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Homer2 homer scaffold protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29547, updated on 9-Dec-2024

    Summary

    Official Symbol
    Homer2provided by RGD
    Official Full Name
    homer scaffold protein 2provided by RGD
    Primary source
    RGD:620705
    See related
    EnsemblRapid:ENSRNOG00000061450 AllianceGenome:RGD:620705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vesl-2
    Summary
    Enables G protein-coupled glutamate receptor binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including G protein-coupled glutamate receptor signaling pathway; negative regulation of calcineurin-NFAT signaling cascade; and negative regulation of interleukin-2 production. Predicted to act upstream of or within behavioral response to cocaine; calcium-mediated signaling; and regulation of G protein-coupled receptor signaling pathway. Located in dendrite; neuronal cell body; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 97.7), Heart (RPKM 88.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Homer2 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144968207..145069022, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135558977..135659780, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143443300..143535579, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA76 Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene WASP homolog associated with actin, golgi membranes and microtubules Neighboring gene RNA, U6 small nuclear 946 Neighboring gene similar to human chromosome 15 open reading frame 40 Neighboring gene RNA guanine-7 methyltransferase activating subunit Neighboring gene BTB domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled glutamate receptor binding  
    enables G protein-coupled glutamate receptor binding  
    enables G protein-coupled glutamate receptor binding PubMed 
    enables actin binding  
    enables actin binding  
    enables glutamate receptor binding PubMed 
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein-containing complex binding PubMed 
    enables synaptic receptor adaptor activity  
    enables synaptic receptor adaptor activity  
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway  
    involved_in G protein-coupled glutamate receptor signaling pathway  
    involved_in behavioral response to cocaine  
    acts_upstream_of_or_within behavioral response to cocaine  
    involved_in calcium-mediated signaling  
    acts_upstream_of_or_within calcium-mediated signaling  
    involved_in negative regulation of calcineurin-NFAT signaling cascade  
    involved_in negative regulation of calcineurin-NFAT signaling cascade  
    involved_in negative regulation of calcineurin-NFAT signaling cascade  
    involved_in negative regulation of interleukin-2 production  
    involved_in negative regulation of interleukin-2 production  
    involved_in negative regulation of interleukin-2 production  
    involved_in regulation of G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway  
    involved_in regulation of store-operated calcium entry  
    involved_in sensory perception of sound  
    involved_in sensory perception of sound  
    involved_in sensory perception of sound  
    Component Evidence Code Pubs
    located_in apical part of cell  
    located_in apical part of cell  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in dendrite  
    located_in dendrite PubMed 
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in neuronal cell body PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    is_active_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in postsynaptic density  
    located_in stereocilium tip  
    located_in stereocilium tip  
    located_in stereocilium tip  

    General protein information

    Preferred Names
    homer protein homolog 2
    Names
    VASP/Ena-related gene up-regulated during seizure and LTP 2
    cupidin
    homer homolog 2
    homer scaffolding protein 2
    homer, neuronal immediate early gene, 2
    homer-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053309.2NP_445761.1  homer protein homolog 2

      See identical proteins and their annotated locations for NP_445761.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88801, O88802
      UniProtKB/TrEMBL
      A0A8I6GHM8, A6JCH3
      Related
      ENSRNOP00000070858.1, ENSRNOT00000087785.3
      Conserved Domains (3) summary
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      pfam07851
      Location:186269
      TMPIT; TMPIT-like protein
      cl23720
      Location:230328
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      144968207..145069022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109538.2XP_038965466.1  homer protein homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GHM8, A6JCH2
      Conserved Domains (2) summary
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      TIGR02168
      Location:98331
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. XM_039109542.2XP_038965470.1  homer protein homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GHM8
      Conserved Domains (2) summary
      TIGR02168
      Location:103278
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:147
      PH-like; Pleckstrin homology-like domain
    3. XM_063287628.1XP_063143698.1  homer protein homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GHM8
    Loading
    Loading
    External link. Please review our privacy policy.