Edn3 endothelin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Edn3provided by RGD
Official Full Name: endothelin 3provided by RGD
Primary source: RGD:2534
See related: EnsemblRapid:ENSRNOG00000007477 AllianceGenome:RGD:2534
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Et3; RGD1564825; preproET-3
Summary: Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in negative regulation of hormone secretion and regulation of neurotransmitter secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome; and Waardenburg syndrome type 4B. Orthologous to human EDN3 (endothelin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 29.8), Lung (RPKM 28.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (183980458..184004958)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (163562307..163586636)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (172856730..172879276)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel bidirectional interaction exists between endothelin-3 and retinoic acid in rat enteric nervous system precursors.
Title: A novel bidirectional interaction between endothelin-3 and retinoic acid in rat enteric nervous system precursors.
ET-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and nitric oxide production
Title: Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor.
Present findings show a clear interaction between the endothelin system, and the catecholaminergic transmission in the olfactory bulb.
Title: Short-term effects of endothelins on tyrosine hydroxylase activity and expression in the olfactory bulb of normotensive rats.
ET-3 significantly contributes to pulmonary vasoconstriction by activating the ET(B) at low concentration, and the ET(A) at high concentration.
Title: Endothelin-3-dependent pulmonary vasoconstriction in monocrotaline-induced pulmonary arterial hypertension.
Present results permit us to conclude that both endothelins play an important role in the regulation of norepinephrine neurotransmission at the presynaptic nerve endings in the hypothalamus.
Title: Regulation of the neuronal norepinephrine transporter by endothelin-1 and -3 in the rat anterior and posterior hypothalamus.
Plays an important role in the growth control of colonic epithelial cells, possibly by mediating epithelial-mesenchymal interactions.
Title: Endothelin-3 controls growth of colonic epithelial cells by mediating epithelial-mesenchymal interaction.
ET-3 effects on bile secretion are dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations.
Title: Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway.
The pronounced increase of endothelin-3 in the renal medulla is associated with preservation of local Nitric Oxide metabolite levels
Title: Anatomically distinct activation of endothelin-3 and the L-arginine/nitric oxide pathway in the kidney with advanced aging.
ET-3-induced hemodynamic alterations are mediated by both ET-A and ET-B receptors
Title: Endothelin-3 induced mesenteric vasoconstriction and PMN infiltration in the rat small intestine: role of endothelin receptors.
ET-1, ET-3, ECE-1, and ET(A) and ET(B) receptor subtype mRNAs are expressed at higher levels in the vas deferens of 3 week old rats as compared with 3 month- and 22 month- old rats
Title: Age-related changes in the properties of the endothelin receptor system at protein and mRNA levels in the rat vas deferens.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

D3Mco79 (e-PCR)
- UniSTS:517955

D3Mco80 (e-PCR)
- UniSTS:517991

Edn3 (e-PCR), detects polymorphism
- UniSTS:142962

d3mgh10 (e-PCR)
- UniSTS:121776

RH87725 (e-PCR)
- UniSTS:119221

U85920 (e-PCR)
- UniSTS:31454

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bombesin receptor binding	TAS Traceable Author Statement more info	PubMed
enables endothelin B receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin B receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in axon extension	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular magnesium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neural crest cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in peptide hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of developmental pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of systemic arterial blood pressure by endothelin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by endothelin	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in regulation of vasoconstriction	TAS Traceable Author Statement more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in vein smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vein smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelin-3

Names: ET-3; PPET3; preproendothelin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077650.2 → NP_001071118.2 endothelin-3 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P13207

UniProtKB/TrEMBL

F1LQB0

Related

ENSRNOP00000009826.4, ENSRNOT00000009826.7

Conserved Domains (2) summary

smart00272
Location:114 → 135

END; Endothelin

pfam00322
Location:49 → 77

Endothelin; Endothelin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

183980458..184004958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284294.1 → XP_063140364.1 endothelin-3 isoform X3
XM_039105615.2 → XP_038961543.1 endothelin-3 isoform X4

UniProtKB/TrEMBL

A6KL41

Conserved Domains (2) summary

smart00272
Location:158 → 179

END; Endothelin

pfam00322
Location:93 → 121

Endothelin; Endothelin family
XM_039105613.2 → XP_038961541.1 endothelin-3 isoform X1

UniProtKB/TrEMBL

A6KL41

Conserved Domains (2) summary

smart00272
Location:182 → 203

END; Endothelin

pfam00322
Location:117 → 145

Endothelin; Endothelin family
XM_039105614.2 → XP_038961542.1 endothelin-3 isoform X2

Conserved Domains (1) summary

pfam00322
Location:117 → 145

Endothelin; Endothelin family