Trdmt1 tRNA aspartic acid methyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trdmt1provided by RGD
Official Full Name: tRNA aspartic acid methyltransferase 1provided by RGD
Primary source: RGD:1306292
See related: EnsemblRapid:ENSRNOG00000026132 AllianceGenome:RGD:1306292
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dnmt2
Summary: Predicted to enable tRNA (cytidine-5-)-methyltransferase activity. Involved in response to amphetamine. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TRDMT1 (tRNA aspartic acid methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 89.6), Thymus (RPKM 88.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (81510740..81554036, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (76601966..76646104, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (80824652..80859585, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-kappaB/MAPK-TNF-alpha pathway.
Title: TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-α pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (cytidine-5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA (cytidine-5-)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within tRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in tRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA (cytosine(38)-C(5))-methyltransferase

Names: DNA (cytosine-5)-methyltransferase-like protein 2; DNA methyltransferase 2; tRNA (cytosine-5-)-methyltransferase

NP_001026813.1

EC 2.1.1.204

XP_063132319.1

EC 2.1.1.204

XP_063132320.1

EC 2.1.1.204

XP_063132321.1

EC 2.1.1.204

XP_063132322.1

EC 2.1.1.204

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031643.1 → NP_001026813.1 tRNA (cytosine(38)-C(5))-methyltransferase

See identical proteins and their annotated locations for NP_001026813.1

Status: PROVISIONAL

Source sequence(s)

BC098700

UniProtKB/Swiss-Prot

Q4G073

UniProtKB/TrEMBL

A0A8I5YBX0, A6JM42

Related

ENSRNOP00000077582.1, ENSRNOT00000112273.2

Conserved Domains (1) summary

cd00315
Location:4 → 391

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

81510740..81554036 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276250.1 → XP_063132320.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform X2

UniProtKB/TrEMBL

A0A8I5YBX0
XM_063276251.1 → XP_063132321.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform X3

UniProtKB/TrEMBL

A0A8I5YBX0
XM_063276249.1 → XP_063132319.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform X1

UniProtKB/TrEMBL

A0A8I5YBX0

Related

ENSRNOP00000111097.1, ENSRNOT00000152886.1
XM_063276252.1 → XP_063132322.1 tRNA (cytosine(38)-C(5))-methyltransferase isoform X4