U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gpr12 G protein-coupled receptor 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80840, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gpr12provided by RGD
    Official Full Name
    G protein-coupled receptor 12provided by RGD
    Primary source
    RGD:68333
    See related
    EnsemblRapid:ENSRNOG00000039832 AllianceGenome:RGD:68333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpcr12
    Summary
    Predicted to enable G protein-coupled receptor activity and phosphatidylcholine binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and intracellular calcium ion homeostasis. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human GPR12 (G protein-coupled receptor 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 22.1), Thymus (RPKM 6.6) and 1 other tissue See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gpr12 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13636549..13640083)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8522709..8525875)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10253710..10257135)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095887 Neighboring gene uncharacterized LOC134481154 Neighboring gene uncharacterized LOC120095888 Neighboring gene uncharacterized LOC120095929

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells. Lu X, et al. Brain Res Bull, 2012 Jan 4. PMID 21985983
    2. Cloning, sequencing and tissue distribution of a candidate G protein-coupled receptor from rat pituitary gland. Eidne KA, et al. FEBS Lett, 1991 Nov 4. PMID 1840531
    3. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. Ignatov A, et al. J Neurosci, 2003 Feb 1. PMID 12574419, Free PMC Article
    4. The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes. Hinckley M, et al. Dev Biol, 2005 Nov 15. PMID 16229830
    5. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. Song ZH, et al. Genomics, 1995 Jul 20. PMID 8530049

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings indicate that GPR12 may play a role in neurite outgrowth during PC12 cell differentiation.
      Title: Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells.
    2. the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12
      Title: The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC156481

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    G-protein coupled receptor 12
    Names
    R334

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037295.2 → NP_001032372.1  G-protein coupled receptor 12

      See identical proteins and their annotated locations for NP_001032372.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      A0JPJ1, P30951
      UniProtKB/TrEMBL
      A6K1C8
      Related
      ENSRNOP00000075912.1, ENSRNOT00000092720.3
      Conserved Domains (1) summary
      cd15961
      Location:45 → 312
      7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_030831.2 → NP_110458.1  G-protein coupled receptor 12

      See identical proteins and their annotated locations for NP_110458.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      A0JPJ1, P30951
      UniProtKB/TrEMBL
      A6K1C8
      Related
      ENSRNOP00000112843.1, ENSRNOT00000121921.1
      Conserved Domains (1) summary
      cd15961
      Location:45 → 312
      7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      13636549..13640083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598463.3 → XP_017453952.1  G-protein coupled receptor 12 isoform X1

    2. XM_039089797.2 → XP_038945725.1  G-protein coupled receptor 12 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:35 → 64
      7tm_GPCRs; TM helix 5 [structural motif]
      cl28897
      Location:1 → 153
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30951.3 GenPept UniProtKB/Swiss-Prot:P30951

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools