U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    App amyloid beta precursor protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54226, updated on 27-Dec-2024

    Summary

    Official Symbol
    Appprovided by RGD
    Official Full Name
    amyloid beta precursor proteinprovided by RGD
    Primary source
    RGD:2139
    See related
    EnsemblRapid:ENSRNOG00000006997 AllianceGenome:RGD:2139
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abeta
    Summary
    Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to cAMP; cellular response to norepinephrine stimulus; and defense response to other organism. Located in several cellular components, including astrocyte projection; axon; and cell surface. Is active in neuronal dense core vesicle. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and traumatic brain injury. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1960.2), Lung (RPKM 1647.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See App in Genome Data Viewer
    Location:
    11q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (37506207..37724351, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (24019774..24236584, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24425013..24641872, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene junctional adhesion molecule 2 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene uncharacterized LOC134480962 Neighboring gene cysteine and tyrosine rich 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 40
    Function Evidence Code Pubs
    enables DNA binding  
    enables G protein-coupled receptor binding  
    enables PTB domain binding  
    enables PTB domain binding  
    enables RAGE receptor binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables acetylcholine receptor binding  
    enables apolipoprotein binding  
    enables chemoattractant activity  
    enables chromatin binding  
    enables enzyme binding  
    enables ephrin receptor binding  
    enables frizzled binding  
    enables growth factor receptor binding PubMed 
    enables heparan sulfate proteoglycan binding  
    enables heparin binding  
    enables identical protein binding  
    enables identical protein binding  
    enables insulin receptor binding  
    enables integrin binding  
    enables low-density lipoprotein particle receptor binding  
    enables peptidase activator activity PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase binding  
    enables protein serine/threonine kinase binding  
    enables protein serine/threonine kinase binding  
    enables protein-folding chaperone binding  
    enables receptor ligand activity  
    enables receptor ligand activity  
    enables serine-type endopeptidase inhibitor activity  
    enables serine-type endopeptidase inhibitor activity  
    enables signaling receptor activator activity  
    enables signaling receptor activator activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables transition metal ion binding  
    Items 1 - 25 of 40
    Items 1 - 25 of 227
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G2/M transition of mitotic cell cycle  
    acts_upstream_of G2/M transition of mitotic cell cycle  
    involved_in Notch signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    involved_in adult locomotory behavior  
    acts_upstream_of_or_within adult locomotory behavior  
    involved_in adult locomotory behavior  
    involved_in amyloid fibril formation  
    involved_in amyloid fibril formation  
    involved_in antibacterial humoral response PubMed 
    involved_in antifungal humoral response PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in associative learning  
    involved_in astrocyte activation  
    involved_in astrocyte activation involved in immune response  
    involved_in astrocyte activation involved in immune response  
    involved_in axo-dendritic transport  
    NOT acts_upstream_of_or_within axo-dendritic transport  
    acts_upstream_of_or_within axo-dendritic transport  
    involved_in axo-dendritic transport  
    involved_in axon midline choice point recognition  
    acts_upstream_of_or_within axon midline choice point recognition  
    involved_in axon midline choice point recognition  
    involved_in axonogenesis  
    acts_upstream_of_or_within axonogenesis  
    involved_in axonogenesis  
    involved_in calcium-mediated signaling  
    involved_in cell adhesion  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to cAMP PubMed 
    involved_in cellular response to copper ion PubMed 
    involved_in cellular response to manganese ion PubMed 
    involved_in cellular response to nerve growth factor stimulus PubMed 
    involved_in cellular response to norepinephrine stimulus PubMed 
    involved_in central nervous system development  
    NOT involved_in chemical synaptic transmission  
    involved_in cholesterol metabolic process  
    acts_upstream_of_or_within cholesterol metabolic process  
    acts_upstream_of_or_within cognition  
    acts_upstream_of_or_within cognition  
    involved_in collateral sprouting in absence of injury  
    acts_upstream_of_or_within collateral sprouting in absence of injury  
    involved_in collateral sprouting in absence of injury  
    involved_in cytosolic mRNA polyadenylation  
    acts_upstream_of_or_within cytosolic mRNA polyadenylation  
    involved_in defense response to Gram-negative bacterium PubMed 
    involved_in defense response to Gram-positive bacterium PubMed 
    involved_in dendrite development  
    acts_upstream_of_or_within dendrite development  
    involved_in dendrite development  
    involved_in endocytosis  
    acts_upstream_of_or_within endocytosis  
    involved_in endocytosis  
    involved_in extracellular matrix organization  
    acts_upstream_of_or_within extracellular matrix organization  
    involved_in extracellular matrix organization  
    involved_in forebrain development  
    acts_upstream_of_or_within forebrain development  
    involved_in gene expression  
    acts_upstream_of_or_within gene expression  
    involved_in innate immune response PubMed 
    involved_in innate immune response  
    involved_in intracellular copper ion homeostasis  
    acts_upstream_of_or_within intracellular copper ion homeostasis  
    involved_in intracellular copper ion homeostasis  
    involved_in ionotropic glutamate receptor signaling pathway  
    acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway  
    involved_in ionotropic glutamate receptor signaling pathway  
    involved_in learning  
    involved_in learning or memory  
    acts_upstream_of_or_within locomotory behavior  
    involved_in locomotory behavior  
    involved_in low-density lipoprotein particle mediated signaling  
    involved_in mating behavior  
    acts_upstream_of_or_within mating behavior  
    involved_in mating behavior  
    involved_in memory  
    involved_in microglia development  
    involved_in microglia development  
    involved_in microglial cell activation  
    involved_in microglial cell activation  
    acts_upstream_of mitotic cell cycle  
    involved_in modulation of excitatory postsynaptic potential  
    involved_in modulation of excitatory postsynaptic potential  
    involved_in negative regulation of blood circulation  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of long-term synaptic potentiation  
    involved_in negative regulation of long-term synaptic potentiation  
    involved_in negative regulation of miRNA transcription  
    involved_in negative regulation of neuron differentiation  
    acts_upstream_of_or_within negative regulation of neuron differentiation  
    involved_in negative regulation of presynapse assembly  
    acts_upstream_of_or_within negative regulation of presynapse assembly  
    involved_in negative regulation of protein localization to nucleus  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in neuromuscular process controlling balance  
    acts_upstream_of_or_within neuromuscular process controlling balance  
    involved_in neuron apoptotic process  
    acts_upstream_of_or_within neuron apoptotic process  
    involved_in neuron cellular homeostasis  
    acts_upstream_of_or_within neuron cellular homeostasis  
    acts_upstream_of neuron differentiation  
    acts_upstream_of_or_within neuron projection development  
    involved_in neuron projection development  
    involved_in neuron projection maintenance  
    involved_in neuron projection maintenance  
    involved_in neuron remodeling  
    acts_upstream_of_or_within neuron remodeling  
    involved_in neuron remodeling  
    acts_upstream_of_positive_effect phospholipase D-activating G protein-coupled receptor signaling pathway  
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of G protein-coupled receptor internalization  
    involved_in positive regulation of G protein-coupled receptor signaling pathway  
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of T cell migration  
    involved_in positive regulation of T cell migration  
    involved_in positive regulation of Toll signaling pathway  
    involved_in positive regulation of amyloid fibril formation  
    involved_in positive regulation of amyloid fibril formation  
    involved_in positive regulation of amyloid precursor protein catabolic process  
    acts_upstream_of positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cAMP/PKA signal transduction  
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of endothelin production  
    involved_in positive regulation of excitatory postsynaptic potential  
    involved_in positive regulation of extrinsic apoptotic signaling pathway  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression, epigenetic  
    involved_in positive regulation of glycolytic process  
    involved_in positive regulation of glycolytic process  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of long-term synaptic potentiation  
    involved_in positive regulation of long-term synaptic potentiation  
    involved_in positive regulation of membrane protein ectodomain proteolysis  
    acts_upstream_of_or_within positive regulation of mitotic cell cycle  
    involved_in positive regulation of mitotic cell cycle  
    involved_in positive regulation of monocyte chemotaxis  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of peptidyl-threonine phosphorylation  
    NOT involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of protein import  
    involved_in positive regulation of protein metabolic process PubMed 
    involved_in positive regulation of protein metabolic process  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of response to endoplasmic reticulum stress  
    involved_in positive regulation of superoxide anion generation  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type II interferon production  
    involved_in protein homooligomerization  
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein tetramerization  
    involved_in protein trimerization  
    involved_in regulation of amyloid fibril formation  
    acts_upstream_of regulation of amyloid-beta clearance  
    NOT involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  
    involved_in regulation of dendritic spine maintenance  
    involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  
    acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of gene expression  
    involved_in regulation of long-term neuronal synaptic plasticity  
    involved_in regulation of long-term neuronal synaptic plasticity  
    involved_in regulation of multicellular organism growth  
    acts_upstream_of_or_within regulation of multicellular organism growth  
    involved_in regulation of multicellular organism growth  
    involved_in regulation of neurotransmitter uptake  
    involved_in regulation of peptidyl-tyrosine phosphorylation  
    involved_in regulation of presynapse assembly  
    involved_in regulation of response to calcium ion PubMed 
    involved_in regulation of spontaneous synaptic transmission  
    involved_in regulation of spontaneous synaptic transmission  
    acts_upstream_of_or_within regulation of synapse structure or activity  
    involved_in regulation of synapse structure or activity  
    involved_in regulation of toll-like receptor signaling pathway  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of translation  
    acts_upstream_of_or_within regulation of translation  
    involved_in regulation of translation  
    NOT involved_in response to auditory stimulus  
    involved_in response to interleukin-1 PubMed 
    involved_in response to lead ion PubMed 
    involved_in response to oxidative stress  
    acts_upstream_of_or_within response to oxidative stress  
    involved_in response to yeast PubMed 
    involved_in smooth endoplasmic reticulum calcium ion homeostasis  
    acts_upstream_of_or_within smooth endoplasmic reticulum calcium ion homeostasis  
    involved_in suckling behavior  
    acts_upstream_of_or_within suckling behavior  
    involved_in synapse organization  
    involved_in synaptic assembly at neuromuscular junction  
    acts_upstream_of_or_within synaptic assembly at neuromuscular junction  
    involved_in visual learning  
    acts_upstream_of_or_within visual learning  
    involved_in visual learning  
    Items 1 - 25 of 227
    Items 1 - 20 of 100
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle  
    located_in COPII-coated ER to Golgi transport vesicle  
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi-associated vesicle  
    located_in Golgi-associated vesicle  
    located_in Golgi-associated vesicle  
    part_of amyloid-beta complex  
    located_in apical part of cell  
    located_in apical part of cell  
    located_in astrocyte projection PubMed 
    located_in axon PubMed 
    is_active_in axon  
    located_in axon  
    located_in axon  
    located_in cell body  
    is_active_in cell surface  
    located_in cell surface PubMed 
    located_in cell surface  
    is_active_in cell surface  
    located_in cell surface  
    located_in cell-cell junction  
    located_in cell-cell junction  
    located_in ciliary rootlet  
    located_in ciliary rootlet  
    located_in clathrin-coated pit  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic vesicle  
    NOT located_in dendrite  
    is_active_in dendrite  
    NOT located_in dendrite membrane  
    located_in dendritic shaft  
    located_in dendritic shaft  
    located_in dendritic spine  
    located_in dendritic spine  
    is_active_in early endosome  
    located_in early endosome  
    located_in early endosome  
    located_in early endosome  
    located_in endoplasmic reticulum  
    located_in endosome  
    located_in endosome to plasma membrane transport vesicle  
    NOT located_in external side of plasma membrane  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in growth cone PubMed 
    located_in growth cone  
    located_in growth cone filopodium PubMed 
    located_in growth cone lamellipodium PubMed 
    part_of high-density lipoprotein particle  
    part_of intermediate-density lipoprotein particle  
    is_active_in intracellular vesicle  
    part_of lipoprotein particle  
    part_of low-density lipoprotein particle  
    located_in lysosome  
    located_in main axon PubMed 
    located_in membrane  
    located_in membrane  
    is_active_in membrane raft  
    located_in membrane raft  
    located_in membrane raft  
    located_in mitochondrion  
    located_in neuromuscular junction  
    located_in neuromuscular junction  
    located_in neuron projection  
    is_active_in neuronal dense core vesicle PubMed 
    located_in nuclear envelope lumen  
    located_in nuclear envelope lumen  
    located_in nucleus  
    located_in perikaryon  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    located_in presynapse  
    located_in presynaptic active zone  
    is_active_in presynaptic active zone  
    part_of protein-containing complex  
    part_of receptor complex  
    part_of receptor complex  
    located_in recycling endosome  
    located_in recycling endosome  
    located_in recycling endosome  
    located_in smooth endoplasmic reticulum  
    located_in spindle midzone  
    located_in spindle midzone  
    located_in synapse  
    NOT located_in synaptic membrane  
    NOT located_in synaptic vesicle PubMed 
    located_in synaptic vesicle  
    located_in synaptic vesicle  
    located_in terminal bouton PubMed 
    part_of very-low-density lipoprotein particle  
    Items 1 - 20 of 100

    General protein information

    Preferred Names
    amyloid-beta precursor protein
    Names
    ABPP
    AG
    alzheimer disease amyloid A4 protein homolog
    alzheimer disease amyloid protein
    amyloid A4
    amyloid beta (A4) precursor protein
    amyloid beta A4 protein
    amyloid precursor protein
    amyloidogenic glycoprotein
    beta-amyloid precursor protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019288.2NP_062161.1  amyloid-beta precursor protein precursor

      See identical proteins and their annotated locations for NP_062161.1

      Status: PROVISIONAL

      Source sequence(s)
      AF513015
      UniProtKB/Swiss-Prot
      P08592, Q547B7
      UniProtKB/TrEMBL
      A0A8L2QLQ8, A6JL62
      Related
      ENSRNOP00000111736.1, ENSRNOT00000164631.1
      Conserved Domains (5) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294341
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam03494
      Location:677713
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:716766
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:366548
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      37506207..37724351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248011.5XP_006248073.1  amyloid-beta precursor protein isoform X4

      See identical proteins and their annotated locations for XP_006248073.1

      UniProtKB/TrEMBL
      A0A8L2QLQ8, A6JL61
      Related
      ENSRNOP00000041613.5, ENSRNOT00000048854.8
      Conserved Domains (6) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:600638
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:641691
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:291473
      APP_E2; E2 domain of amyloid precursor protein
    2. XM_006248009.5XP_006248071.1  amyloid-beta precursor protein isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHW9, A0A8L2QLQ8
      Related
      ENSRNOP00000040243.5, ENSRNOT00000044081.7
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:656694
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:697747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein
    3. XM_006248008.5XP_006248070.1  amyloid-beta precursor protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y8G9, A0A8L2QLQ8
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:657695
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:698748
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:366548
      APP_E2; E2 domain of amyloid precursor protein
    4. XM_006248012.5XP_006248074.1  amyloid-beta precursor protein isoform X5

      UniProtKB/TrEMBL
      A0A8L2QLQ8
      Conserved Domains (6) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:582620
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:623673
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:291473
      APP_E2; E2 domain of amyloid precursor protein
    5. XM_006248010.5XP_006248072.1  amyloid-beta precursor protein isoform X3

      See identical proteins and their annotated locations for XP_006248072.1

      UniProtKB/TrEMBL
      A0A8L2QLQ8, Q6P6Q5
      Related
      ENSRNOP00000078198.2, ENSRNOT00000104573.2
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:638676
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:679729
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein
    6. XM_063270722.1XP_063126792.1  amyloid-beta precursor protein isoform X6

    External link. Please review our privacy policy.