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    Map3k4 mitogen activated protein kinase kinase kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Map3k4provided by RGD
    Official Full Name
    mitogen activated protein kinase kinase kinase 4provided by RGD
    Primary source
    RGD:1311192
    See related
    EnsemblRapid:ENSRNOG00000017419 AllianceGenome:RGD:1311192
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in p38MAPK cascade; positive regulation of p38MAPK cascade; and response to UV-C. Predicted to act upstream of or within several processes, including chorionic trophoblast cell differentiation; male germ-line sex determination; and positive regulation of macromolecule metabolic process. Predicted to be located in cytoplasm. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 104.1), Heart (RPKM 86.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map3k4 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50977870..51067117)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (48431801..48519358)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48625714..48711642)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene deoxyuridine triphosphatase pseudogene Neighboring gene uncharacterized LOC120099124 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene uncharacterized LOC108349099 Neighboring gene uncharacterized LOC134482716

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models. Huang L, et al. J Cell Physiol, 2020 Apr. PMID 31602666
    2. Sex reversal in XY mice caused by dominant mutation on chromosome 17. Washburn LL, et al. Nature, 1983 May 26. PMID 6855886
    3. The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Liu H, et al. Free Radic Res, 2006 Aug. PMID 17015265, Free PMC Article
    4. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. Takekawa M, et al. EMBO J, 1997 Aug 15. PMID 9305639, Free PMC Article
    5. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Takekawa M, et al. Cell, 1998 Nov 13. PMID 9827804

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models.
      Title: Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models.
    2. ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages
      Title: The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within chorionic trophoblast cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male germ-line sex determination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV-C ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 4
    NP_001100926.1
    NP_001388382.1
    NP_001402774.1
    XP_038966489.1
    XP_038966502.1
    XP_063144502.1
    XP_063144507.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107456.3 → NP_001100926.1  mitogen-activated protein kinase kinase kinase 4 isoform 2

      See identical proteins and their annotated locations for NP_001100926.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZTM8, A6KJY7, D3ZGU6
      Related
      ENSRNOP00000062453.1, ENSRNOT00000064018.5
      Conserved Domains (2) summary
      smart00220
      Location:1122 → 1380
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06626
      Location:1121 → 1380
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

    2. NM_001401453.2 → NP_001388382.1  mitogen-activated protein kinase kinase kinase 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K3R1, A0A8I5ZUS1
      Related
      ENSRNOP00000072741.1, ENSRNOT00000084317.3

    3. NM_001415845.1 → NP_001402774.1  mitogen-activated protein kinase kinase kinase 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZUS1, A0A8I6GLL3
      Related
      ENSRNOP00000096435.1, ENSRNOT00000116657.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      50977870..51067117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288432.1 → XP_063144502.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

    2. XM_039110574.2 → XP_038966502.1  mitogen-activated protein kinase kinase kinase 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUS1
      Related
      ENSRNOP00000106526.1, ENSRNOT00000171818.1
      Conserved Domains (1) summary
      cd06626
      Location:1252 → 1511
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

    3. XM_039110561.2 → XP_038966489.1  mitogen-activated protein kinase kinase kinase 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTM8
      Related
      ENSRNOP00000081978.1, ENSRNOT00000094132.2
      Conserved Domains (1) summary
      cd06626
      Location:1323 → 1582
      STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

    4. XM_063288437.1 → XP_063144507.1  mitogen-activated protein kinase kinase kinase 4 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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