Bid BH3 interacting domain death agonist [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bidprovided by RGD
Official Full Name: BH3 interacting domain death agonistprovided by RGD
Primary source: RGD:620160
See related: EnsemblRapid:ENSRNOG00000012439 AllianceGenome:RGD:620160
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin protein ligase binding activity. Involved in several processes, including apoptotic mitochondrial changes; positive regulation of autophagy in response to ER overload; and positive regulation of release of cytochrome c from mitochondria. Located in cytosol and mitochondrion. Used to study pre-malignant neoplasm. Biomarker of bronchopulmonary dysplasia; epilepsy; status epilepticus; and traumatic brain injury. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human BID (BH3 interacting domain death agonist). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 211.1), Spleen (RPKM 175.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (155785366..155808775, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (154113198..154136353, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (153439812..153465247, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush.
Title: Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush.
ANXA1 interacts with p53 and promotes p53 transcriptional activity, which in turn regulates Bid expression.
Title: Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding.
disruption of the CHOP/BH3 gene expression homeostasis is detrimental to cell survival independent of other cellular stress.
Title: Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression.
By blocking he tBid-mitochondrial apoptotic signaling pathway, neuroprotection against cerebral ischemia is activated.
Title: Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway.
act in synergy with Bax in T11TS-mediated glioma apoptosis
Title: Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation.
tBid has a monofunctional action at low concentrations and basal cytochrome c diffusibility in the intermembrane spaces is adequate for rapid and complete cytochrome c release irrespective of outer membrane permeabilisation.
Title: Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release.
BIM and tBID follow different strategies to trigger BAX-driven mitochondrial outer membrane permeabilization with strong potency
Title: BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes.
Suggest that estrogen protects the heart against ischemia reperfusion injury through the decrease of calpain activity, Bid cleavage and caspase-8 activity.
Title: Estrogen attenuates cardiac ischemia-reperfusion injury via inhibition of calpain-mediated bid cleavage.
In contrast to Bax, another pro-apoptotic protein (Bid) proteolytically cleaved with caspase-8 affected the voltage gating of voltage-dependent anion channels by inducing channel closure.
Title: Bid, but not Bax, regulates VDAC channels.
Kainic acid evoked seizures triggered Bid protein cleavage and a commensurate increase in binding of Bid to 14-3-3 within injured hippocampus suggesting 14-3-3 proteins may target active and inactive conformations of pro-apoptotic Bcl-2 death agonists
Title: Interaction of 14-3-3 with Bid during seizure-induced neuronal death.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic mitochondrial changes	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glial cell apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial ATP synthesis coupled electron transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial outer membrane permeabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial outer membrane permeabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy in response to ER overload	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in response to cisplatin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
involved_in supramolecular fiber organization	IEA Inferred from Electronic Annotation more info
involved_in supramolecular fiber organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BH3-interacting domain death agonist

Names: apoptotic death agonist BID; desmocollin type 4; p22 BID

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022684.2 → NP_073175.1 BH3-interacting domain death agonist

See identical proteins and their annotated locations for NP_073175.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q9JK60, Q9JLT6

UniProtKB/TrEMBL

A0A8I5ZKS3, A8ASI9

Related

ENSRNOP00000016776.2, ENSRNOT00000016776.4

Conserved Domains (1) summary

pfam06393
Location:3 → 193

BID; BH3 interacting domain (BID)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

155785366..155808775 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108323.2 → XP_038964251.1 BH3-interacting domain death agonist isoform X2

UniProtKB/Swiss-Prot

Q9JK60, Q9JLT6

UniProtKB/TrEMBL

A0A8I5ZKS3, A8ASI9

Conserved Domains (1) summary

pfam06393
Location:3 → 193

BID; BH3 interacting domain (BID)
XM_063286667.1 → XP_063142737.1 BH3-interacting domain death agonist isoform X1

UniProtKB/TrEMBL

A0A8I5ZKS3
XM_039108322.2 → XP_038964250.1 BH3-interacting domain death agonist isoform X2

UniProtKB/Swiss-Prot

Q9JK60, Q9JLT6

UniProtKB/TrEMBL

A0A8I5ZKS3, A8ASI9

Conserved Domains (1) summary

pfam06393
Location:3 → 193

BID; BH3 interacting domain (BID)
XM_017592880.3 → XP_017448369.1 BH3-interacting domain death agonist isoform X2

UniProtKB/Swiss-Prot

Q9JK60, Q9JLT6

UniProtKB/TrEMBL

A0A8I5ZKS3, A8ASI9

Conserved Domains (1) summary

pfam06393
Location:3 → 193

BID; BH3 interacting domain (BID)