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    Sv2b synaptic vesicle glycoprotein 2b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117556, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sv2bprovided by RGD
    Official Full Name
    synaptic vesicle glycoprotein 2bprovided by RGD
    Primary source
    RGD:619716
    See related
    EnsemblRapid:ENSRNOG00000011160 AllianceGenome:RGD:619716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is active in glutamatergic synapse and synaptic vesicle membrane. Orthologous to human SV2B (synaptic vesicle glycoprotein 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 462.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sv2b in Genome Data Viewer
    Location:
    1q31
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (138388268..138562635, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (128978471..129152479, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (136664199..136842247, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene actin, gamma 1, pseudogene 11 Neighboring gene large ribosomal subunit protein eL13-like Neighboring gene A-kinase anchoring protein 13 Neighboring gene uncharacterized LOC134485139 Neighboring gene family with sequence similarity 24, member A like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in acrosomal vesicle  
    is_active_in glutamatergic synapse PubMed 
    located_in synaptic vesicle PubMed 
    located_in synaptic vesicle  
    is_active_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane  
    located_in terminal bouton PubMed 

    General protein information

    Preferred Names
    synaptic vesicle glycoprotein 2B
    Names
    synaptic vesicle protein 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057207.3NP_476555.1  synaptic vesicle glycoprotein 2B

      See identical proteins and their annotated locations for NP_476555.1

      Status: VALIDATED

      Source sequence(s)
      AI716529, BF285601, BG671769, CB609053, CO402345, DV721065, L10362
      UniProtKB/Swiss-Prot
      Q63564
      Related
      ENSRNOP00000083518.1, ENSRNOT00000015084.8
      Conserved Domains (2) summary
      cd06174
      Location:112305
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      138388268..138562635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588701.3XP_017444190.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    2. XM_008759493.4XP_008757715.1  synaptic vesicle glycoprotein 2B isoform X1

      See identical proteins and their annotated locations for XP_008757715.1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    3. XM_017588700.3XP_017444189.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    4. XM_039080109.2XP_038936037.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    5. XM_008759492.4XP_008757714.1  synaptic vesicle glycoprotein 2B isoform X1

      See identical proteins and their annotated locations for XP_008757714.1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    6. XM_063268675.1XP_063124745.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
    7. XM_063268635.1XP_063124705.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWR6, A6JBZ8
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