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    Mcm4 minichromosome maintenance complex component 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29728, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mcm4provided by RGD
    Official Full Name
    minichromosome maintenance complex component 4provided by RGD
    Primary source
    RGD:3060
    See related
    EnsemblRapid:ENSRNOG00000001833 AllianceGenome:RGD:3060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mcmd4
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in DNA metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and MCM complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 352.3), Spleen (RPKM 230.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mcm4 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (98762599..98776300)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (85258443..85272144)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (89511191..89524892)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene mitotic spindle organizing protein 2B Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene ubiquitin conjugating enzyme E2 V2 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    contributes_to DNA helicase activity  
    enables double-stranded DNA helicase activity  
    enables forked DNA-dependent helicase activity  
    enables four-way junction helicase activity  
    enables hydrolase activity  
    enables single-stranded 3'-5' DNA helicase activity  
    enables single-stranded DNA binding  
    contributes_to single-stranded DNA binding  
    enables single-stranded DNA binding  
    contributes_to single-stranded DNA helicase activity  
    Component Evidence Code Pubs
    part_of CMG complex  
    part_of MCM complex  
    part_of MCM complex  
    located_in membrane  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    DNA replication licensing factor MCM4
    Names
    mini chromosome maintenance deficient 4 homolog
    minichromosome maintenance deficient 4 homolog
    NP_387500.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033651.1NP_387500.1  DNA replication licensing factor MCM4

      See identical proteins and their annotated locations for NP_387500.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6AAZ2, A6JSR9, G3V681
      Related
      ENSRNOP00000002510.5, ENSRNOT00000002510.8
      Conserved Domains (3) summary
      smart00350
      Location:266769
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:165286
      MCM_N; MCM N-terminal domain
      cl21455
      Location:504643
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      98762599..98776300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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