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    Znrf2 zinc and ring finger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362367, updated on 9-Dec-2024

    Summary

    Official Symbol
    Znrf2provided by RGD
    Official Full Name
    zinc and ring finger 2provided by RGD
    Primary source
    RGD:1306645
    See related
    EnsemblRapid:ENSRNOG00000049057 AllianceGenome:RGD:1306645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znrf1
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of autophagosome-lysosome fusion; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Predicted to be located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human ZNRF2 (zinc and ring finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 278.6), Kidney (RPKM 239.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Znrf2 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (85274626..85358083)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83950406..84032676)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (85009350..85090914)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909941 Neighboring gene uncharacterized LOC134486770 Neighboring gene nucleotide-binding oligomerization domain containing 1 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic vesicle membrane  
    located_in endosome  
    located_in fibrillar center  
    located_in fibrillar center  
    is_active_in intracellular membrane-bounded organelle  
    is_active_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    located_in lysosome  
    is_active_in membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in plasma membrane  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ZNRF2
    Names
    zinc and ring finger 1
    zinc and ring finger 2, E3 ubiquitin protein ligase
    NP_001102098.2
    XP_038963726.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108628.2 → NP_001102098.2  E3 ubiquitin-protein ligase ZNRF2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      M0RBD9
      Related
      ENSRNOP00000066872.2, ENSRNOT00000072271.3
      Conserved Domains (1) summary
      cd16694
      Location:201 → 246
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      85274626..85358083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107798.2 → XP_038963726.1  E3 ubiquitin-protein ligase ZNRF2 isoform X1

      UniProtKB/TrEMBL
      M0RBD9
      Conserved Domains (1) summary
      cd16694
      Location:201 → 246
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    RNA

    1. XR_010065675.1 RNA Sequence

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