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    Irak3 interleukin-1 receptor-associated kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314870, updated on 27-Dec-2024

    Summary

    Official Symbol
    Irak3provided by RGD
    Official Full Name
    interleukin-1 receptor-associated kinase 3provided by RGD
    Primary source
    RGD:1308846
    See related
    EnsemblRapid:ENSRNOG00000004226 AllianceGenome:RGD:1308846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein dimerization activity. Predicted to be involved in several processes, including regulation of innate immune response; regulation of macromolecule metabolic process; and response to bacterium. Predicted to act upstream of or within positive regulation of NF-kappaB transcription factor activity and protein autophosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 64.3), Heart (RPKM 58.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Irak3 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (57538522..57600166, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (55653949..55714371, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (64922830..64982224, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 1 Neighboring gene uncharacterized LOC120093802 Neighboring gene DNA helicase B Neighboring gene transmembrane BAX inhibitor motif containing 4 Neighboring gene LLP homolog, long-term synaptic facilitation factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables magnesium ion binding  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase activity  
    enables protein kinase binding  
    enables protein serine/threonine kinase activity  
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in Toll signaling pathway  
    involved_in biological_process  
    involved_in cytokine-mediated signaling pathway  
    involved_in interleukin-1-mediated signaling pathway  
    acts_upstream_of_or_within interleukin-1-mediated signaling pathway  
    involved_in interleukin-1-mediated signaling pathway  
    involved_in intracellular signal transduction  
    involved_in lipopolysaccharide-mediated signaling pathway  
    involved_in negative regulation of MAP kinase activity  
    involved_in negative regulation of NF-kappaB transcription factor activity  
    involved_in negative regulation of innate immune response  
    involved_in negative regulation of interleukin-12 production  
    involved_in negative regulation of interleukin-6 production  
    involved_in negative regulation of macrophage cytokine production  
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of protein-containing complex disassembly  
    involved_in negative regulation of toll-like receptor signaling pathway  
    involved_in negative regulation of tumor necrosis factor production  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of macrophage tolerance induction  
    acts_upstream_of_or_within protein autophosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of protein-containing complex disassembly  
    involved_in response to Gram-negative bacterium  
    involved_in response to Gram-positive bacterium  
    involved_in response to exogenous dsRNA  
    involved_in response to interleukin-1  
    involved_in response to lipopolysaccharide  
    involved_in response to peptidoglycan  
    involved_in toll-like receptor signaling pathway  
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    interleukin-1 receptor-associated kinase 3
    NP_001101571.1
    XP_017450343.1
    XP_038935060.1
    XP_038935061.1
    XP_038935062.1
    XP_038935063.1
    XP_038935064.1
    XP_063119570.1
    XP_063119571.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108101.1 → NP_001101571.1  interleukin-1 receptor-associated kinase 3

      See identical proteins and their annotated locations for NP_001101571.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/TrEMBL
      B2RYC8, F6QZN4
      Related
      ENSRNOP00000005686.3, ENSRNOT00000005686.6
      Conserved Domains (3) summary
      cd08796
      Location:15 → 102
      Death_IRAK-M; Death domain of Interleukin 1 Receptor Associated Kinase-M
      cd14160
      Location:185 → 460
      PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3
      pfam00069
      Location:179 → 455
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      57538522..57600166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079133.2 → XP_038935061.1  interleukin-1 receptor-associated kinase 3 isoform X3

      Conserved Domains (1) summary
      cd14160
      Location:46 → 321
      PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3
    2. XM_017594854.3 → XP_017450343.1  interleukin-1 receptor-associated kinase 3 isoform X1

    3. XM_039079132.2 → XP_038935060.1  interleukin-1 receptor-associated kinase 3 isoform X2

      Conserved Domains (1) summary
      cd14160
      Location:52 → 327
      PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3
    4. XM_039079134.2 → XP_038935062.1  interleukin-1 receptor-associated kinase 3 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:12 → 265
      PKc_like; Protein Kinases, catalytic domain
    5. XM_063263501.1 → XP_063119571.1  interleukin-1 receptor-associated kinase 3 isoform X6

    6. XM_039079135.2 → XP_038935063.1  interleukin-1 receptor-associated kinase 3 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:2 → 213
      PKc_like; Protein Kinases, catalytic domain
    7. XM_063263500.1 → XP_063119570.1  interleukin-1 receptor-associated kinase 3 isoform X5

    8. XM_039079136.2 → XP_038935064.1  interleukin-1 receptor-associated kinase 3 isoform X7

      Conserved Domains (2) summary
      cd08796
      Location:15 → 102
      Death_IRAK-M; Death domain of Interleukin 1 Receptor Associated Kinase-M
      cl21453
      Location:185 → 309
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_005486627.2 RNA Sequence

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