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    Gsdma gasdermin A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360619, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gsdmaprovided by RGD
    Official Full Name
    gasdermin Aprovided by RGD
    Primary source
    RGD:1592062
    See related
    EnsemblRapid:ENSRNOG00000007943 AllianceGenome:RGD:1592062
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gsdma1
    Summary
    Predicted to enable phospholipid binding activity and wide pore channel activity. Predicted to be involved in defense response to bacterium and pyroptotic inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in membrane. Orthologous to human GSDMA (gasdermin A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 6.2), Lung (RPKM 4.8) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Gsdma in Genome Data Viewer
    Location:
    10q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84110590..84135804)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83614336..83639543)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86569898..86595102)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ORMDL sphingolipid biosynthesis regulator 3 Neighboring gene leucine rich repeat containing 3C Neighboring gene proteasome 26S subunit, non-ATPase 3 Neighboring gene colony stimulating factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding  
    enables phosphatidylinositol-4-phosphate binding  
    enables phosphatidylserine binding  
    enables wide pore channel activity  
    Process Evidence Code Pubs
    involved_in defense response to bacterium  
    involved_in defense response to bacterium  
    involved_in programmed cell death  
    involved_in pyroptotic inflammatory response  
    involved_in pyroptotic inflammatory response  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    is_active_in membrane  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  

    General protein information

    Preferred Names
    gasdermin-A
    Names
    gasdermin A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108297.1NP_001101767.1  gasdermin-A

      See identical proteins and their annotated locations for NP_001101767.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HIT3, D3ZA32
      Related
      ENSRNOP00000050054.3, ENSRNOT00000048349.5
      Conserved Domains (1) summary
      pfam04598
      Location:3419
      Gasdermin; Gasdermin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84110590..84135804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247347.3XP_006247409.1  gasdermin-A isoform X1

      See identical proteins and their annotated locations for XP_006247409.1

      UniProtKB/TrEMBL
      A6HIT3, D3ZA32
      Conserved Domains (1) summary
      pfam04598
      Location:3419
      Gasdermin; Gasdermin family
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