U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Lgals9 galectin 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25476, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lgals9provided by RGD
    Official Full Name
    galectin 9provided by RGD
    Primary source
    RGD:3005
    See related
    EnsemblRapid:ENSRNOG00000012681 AllianceGenome:RGD:3005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UAT
    Summary
    Predicted to enable several functions, including disaccharide binding activity; galactoside binding activity; and protein serine/threonine kinase activator activity. Involved in toll-like receptor 3 signaling pathway. Predicted to be located in cytoplasm and extracellular space. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including LGALS9 (galectin 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 203.4), Spleen (RPKM 108.2) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lgals9 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (64405044..64428249, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63907018..63930224, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (64737022..64760195)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene antisense transcript of iNOS gene Neighboring gene nitric oxide synthase 2, pseudogene 1 Neighboring gene nitric oxide synthase 2 Neighboring gene galectin 5 Neighboring gene kinase suppressor of ras 1 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion like 2 Neighboring gene WD repeat and SOCS box-containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding  
    enables carbohydrate binding  
    enables carbohydrate binding  
    enables carbohydrate binding  
    enables disaccharide binding  
    enables enzyme binding  
    enables galactoside binding  
    enables galactoside binding  
    enables protein serine/threonine kinase activator activity  
    enables signaling receptor binding  
    Items 1 - 25 of 74
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade  
    involved_in cellular response to type II interferon  
    involved_in cellular response to virus  
    involved_in female pregnancy  
    involved_in inflammatory response  
    involved_in maintenance of protein location  
    involved_in maternal process involved in female pregnancy  
    NOT involved_in mature conventional dendritic cell differentiation  
    involved_in monoatomic ion transport  
    involved_in natural killer cell tolerance induction  
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation  
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation  
    involved_in negative regulation of activated T cell proliferation  
    involved_in negative regulation of chemokine production  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of mast cell degranulation  
    involved_in negative regulation of natural killer cell activation  
    involved_in negative regulation of natural killer cell degranulation  
    involved_in negative regulation of natural killer cell mediated cytotoxicity  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of type II interferon production  
    involved_in negative regulation of type II interferon production  
    involved_in p38MAPK cascade  
    involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  
    involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  
    involved_in positive regulation of T cell migration  
    involved_in positive regulation of activated T cell autonomous cell death  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of defense response to bacterium  
    involved_in positive regulation of dendritic cell apoptotic process  
    involved_in positive regulation of dendritic cell chemotaxis  
    involved_in positive regulation of dendritic cell differentiation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of innate immune response  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 production  
    involved_in positive regulation of interleukin-10 production  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-13 production  
    involved_in positive regulation of interleukin-4 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of macrophage activation  
    involved_in positive regulation of monocyte chemotactic protein-1 production  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of oxidoreductase activity  
    involved_in positive regulation of regulatory T cell differentiation  
    involved_in positive regulation of transforming growth factor beta production  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type II interferon production  
    involved_in positive regulation of viral entry into host cell  
    involved_in receptor clustering  
    NOT involved_in regulation of T cell chemotaxis  
    NOT involved_in regulation of T cell differentiation in thymus  
    NOT involved_in regulation of T-helper 17 type immune response  
    NOT involved_in regulation of interleukin-4 production  
    NOT involved_in regulation of interleukin-5 production  
    involved_in regulation of natural killer cell differentiation  
    NOT involved_in regulation of p38MAPK cascade  
    involved_in response to interleukin-1  
    involved_in response to lipopolysaccharide  
    NOT involved_in toll-like receptor 2 signaling pathway  
    involved_in toll-like receptor 3 signaling pathway PubMed 
    NOT involved_in toll-like receptor 4 signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    Items 1 - 25 of 74
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in extracellular space  
    is_active_in nucleus  
    located_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    galectin-9
    Names
    36 kDa beta-galactoside-binding lectin
    Lectin, galactose binding, soluble 9 (Galectin-9)
    gal-9
    lectin, galactoside-binding, soluble, 9
    urate transporter/channel

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388499.1NP_001375428.1  galectin-9 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O08588, O35866, P97840
      UniProtKB/TrEMBL
      A6HH79, G3V7N8
      Related
      ENSRNOP00000017042.6, ENSRNOT00000017042.10
      Conserved Domains (1) summary
      smart00908
      Location:231353
      Gal-bind_lectin; Galactoside-binding lectin
    2. NM_001388500.1NP_001375429.1  galectin-9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A1W2Q608, A0A1W2Q6B5
      Related
      ENSRNOP00000076199.2, ENSRNOT00000093232.3
      Conserved Domains (1) summary
      smart00908
      Location:187309
      Gal-bind_lectin; Galactoside-binding lectin
    3. NM_012977.2NP_037109.1  galectin-9 isoform 2

      See identical proteins and their annotated locations for NP_037109.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A1W2Q608, A6HH78, F7ETI8, Q6P7Q6
      Conserved Domains (1) summary
      smart00908
      Location:199321
      Gal-bind_lectin; Galactoside-binding lectin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      64405044..64428249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085282.2XP_038941210.1  galectin-9 isoform X3

      UniProtKB/TrEMBL
      A0A1W2Q608, A0A1W2Q6B5
      Conserved Domains (1) summary
      smart00908
      Location:187309
      Gal-bind_lectin; Galactoside-binding lectin
    2. XM_039085281.2XP_038941209.1  galectin-9 isoform X2

      UniProtKB/TrEMBL
      A0A1W2Q608, A6HH78, F7ETI8, Q6P7Q6
      Conserved Domains (1) summary
      smart00908
      Location:199321
      Gal-bind_lectin; Galactoside-binding lectin
    3. XM_039085280.2XP_038941208.1  galectin-9 isoform X1

      UniProtKB/Swiss-Prot
      O08588, O35866, P97840
      UniProtKB/TrEMBL
      A6HH79, G3V7N8
      Conserved Domains (1) summary
      smart00908
      Location:231353
      Gal-bind_lectin; Galactoside-binding lectin
    External link. Please review our privacy policy.