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    Gkn2 gastrokine 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297419, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gkn2provided by RGD
    Official Full Name
    gastrokine 2provided by RGD
    Primary source
    RGD:1311934
    See related
    EnsemblRapid:ENSRNOG00000009256 AllianceGenome:RGD:1311934
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311934
    Summary
    Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within response to bacterium. Predicted to be located in basal part of cell. Predicted to be active in extracellular space. Orthologous to human GKN2 (gastrokine 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 3.1), Brain (RPKM 1.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gkn2 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121335642..121381680)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119778326..119824366)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119131255..119177329)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene uncharacterized LOC120102329 Neighboring gene gastrokine 1 Neighboring gene gastrokine 3 Neighboring gene bone morphogenetic protein 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in basal part of cell  
    is_active_in extracellular space  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039686.2NP_001034775.1  gastrokine-2 precursor

      See identical proteins and their annotated locations for NP_001034775.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q29TV8
      UniProtKB/TrEMBL
      A6IB04
      Related
      ENSRNOP00000063736.1, ENSRNOT00000067651.4
      Conserved Domains (1) summary
      smart01039
      Location:54149
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      121335642..121381680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107366.1XP_038963294.1  gastrokine-2 isoform X2

      UniProtKB/Swiss-Prot
      Q29TV8
      UniProtKB/TrEMBL
      A6IB04
      Conserved Domains (1) summary
      smart01039
      Location:54149
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
    2. XM_039107365.2XP_038963293.1  gastrokine-2 isoform X1

      Conserved Domains (1) summary
      smart01039
      Location:63158
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
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