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    Srcap Snf2-related CREBBP activator protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361652, updated on 27-Dec-2024

    Summary

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    Symbol
    Srcapprovided by RGD
    Full Name
    Snf2-related CREBBP activator proteinprovided by RGD
    Primary source
    RGD:1565642
    See related
    EnsemblRapid:ENSRNOG00000050282 AllianceGenome:RGD:1565642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565642
    Summary
    Predicted to enable ATP hydrolysis activity and histone binding activity. Predicted to be involved in chromatin remodeling. Predicted to be located in Golgi apparatus; nuclear body; and perinuclear region of cytoplasm. Predicted to be part of Swr1 complex. Human ortholog(s) of this gene implicated in Floating-Harbor syndrome. Orthologous to human SRCAP (Snf2 related CREBBP activator protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 109.7), Spleen (RPKM 102.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srcap in Genome Data Viewer
    Location:
    1q37
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191554043..191607096)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182123562..182172643)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198957764..199007576)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene fibrosin Neighboring gene uncharacterized LOC120099937 Neighboring gene small nucleolar RNA, H/ACA box 30 Neighboring gene transmembrane protein 265 Neighboring gene phosphorylase kinase catalytic subunit gamma 2 Neighboring gene cilia and flagella associated protein 119 Neighboring gene ring finger protein 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP. Ghosh AK, et al. J Biol Chem, 2000 Mar 10. PMID 10702287
    2. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
    3. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, et al. Mol Cell Biol, 2004 Mar. PMID 14966270, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    helicase SRCAP
    Names
    helicase SRCAP-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426934.1 → NP_001413863.1  helicase SRCAP

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZYJ1, A0A8I6AE82
      Related
      ENSRNOP00000084153.1, ENSRNOT00000115655.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191554043..191607096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101211.2 → XP_038957139.1  helicase SRCAP isoform X3

      UniProtKB/TrEMBL
      A0A8I6AE82, M0R750
      Conserved Domains (5) summary
      PHA03247
      Location:1259 → 1796
      PHA03247; large tegument protein UL36; Provisional
      PRK04863
      Location:2183 → 2276
      mukB; chromosome partition protein MukB
      cd18793
      Location:1962 → 2097
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      cd18003
      Location:626 → 848
      DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP
      pfam07529
      Location:127 → 196
      HSA

    2. XM_039101210.2 → XP_038957138.1  helicase SRCAP isoform X2

      UniProtKB/TrEMBL
      A0A8I6AE82
      Conserved Domains (5) summary
      PHA03247
      Location:1271 → 1856
      PHA03247; large tegument protein UL36; Provisional
      PRK04863
      Location:2243 → 2336
      mukB; chromosome partition protein MukB
      cd18793
      Location:2022 → 2157
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      cd18003
      Location:625 → 847
      DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP
      pfam07529
      Location:127 → 196
      HSA

    3. XM_063267796.1 → XP_063123866.1  helicase SRCAP isoform X4

      UniProtKB/TrEMBL
      A0A8I6AE82

    4. XM_039101209.2 → XP_038957137.1  helicase SRCAP isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYJ1, A0A8I6AE82
      Conserved Domains (5) summary
      PHA03247
      Location:1272 → 1857
      PHA03247; large tegument protein UL36; Provisional
      PRK04863
      Location:2244 → 2337
      mukB; chromosome partition protein MukB
      cd18793
      Location:2023 → 2158
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      cd18003
      Location:626 → 848
      DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP
      pfam07529
      Location:127 → 196
      HSA

    5. XM_017590233.3 → XP_017445722.1  helicase SRCAP isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYJ1, A0A8I6AE82
      Conserved Domains (5) summary
      PHA03247
      Location:1272 → 1857
      PHA03247; large tegument protein UL36; Provisional
      PRK04863
      Location:2244 → 2337
      mukB; chromosome partition protein MukB
      cd18793
      Location:2023 → 2158
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      cd18003
      Location:626 → 848
      DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP
      pfam07529
      Location:127 → 196
      HSA

    6. XM_063267792.1 → XP_063123862.1  helicase SRCAP isoform X2

      UniProtKB/TrEMBL
      A0A8I6AE82
    Nucleotide Protein Strain
    Heading Accession and Version

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