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    Terf2 telomeric repeat binding factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361403, updated on 9-Dec-2024

    Summary

    Official Symbol
    Terf2provided by RGD
    Official Full Name
    telomeric repeat binding factor 2provided by RGD
    Primary source
    RGD:1310881
    See related
    EnsemblRapid:ENSRNOG00000020435 AllianceGenome:RGD:1310881
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trf2
    Summary
    Predicted to enable enzyme binding activity; protein homodimerization activity; and telomeric DNA binding activity. Predicted to contribute to telomerase activity. Involved in axonal transport of messenger ribonucleoprotein complex. Predicted to be located in male germ cell nucleus and nuclear body. Predicted to be part of shelterin complex. Predicted to be active in chromosome, telomeric region. Orthologous to human TERF2 (telomeric repeat binding factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 30.2), Thymus (RPKM 29.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Terf2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (51887221..51915756, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (34976963..35005813, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (39271992..39301506, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene nucleolar pre-rRNA processing protein NIP7 Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene uncharacterized LOC134483512 Neighboring gene cytochrome b5 type B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding  
    enables G-rich strand telomeric DNA binding  
    enables double-stranded telomeric DNA binding  
    enables double-stranded telomeric DNA binding  
    enables enzyme binding  
    enables protein homodimerization activity  
    enables protein-containing complex binding  
    contributes_to telomerase activity  
    contributes_to telomerase activity  
    enables telomeric DNA binding  
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in RNA-templated DNA biosynthetic process  
    involved_in axonal transport of messenger ribonucleoprotein complex PubMed 
    involved_in axonal transport of messenger ribonucleoprotein complex PubMed 
    acts_upstream_of_or_within in utero embryonic development  
    involved_in negative regulation of beta-galactosidase activity  
    involved_in negative regulation of cellular senescence  
    involved_in negative regulation of exonuclease activity  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of t-circle formation  
    involved_in negative regulation of telomere capping  
    involved_in negative regulation of telomere maintenance  
    involved_in negative regulation of telomere maintenance via recombination  
    involved_in negative regulation of telomere maintenance via recombination  
    involved_in negative regulation of telomere maintenance via telomerase  
    involved_in negative regulation of telomere maintenance via telomere lengthening  
    involved_in negative regulation of telomeric D-loop disassembly  
    involved_in negative regulation of telomeric D-loop disassembly  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of nitric-oxide synthase activity  
    acts_upstream_of_or_within positive regulation of telomere maintenance  
    involved_in positive regulation of telomere maintenance  
    involved_in protection from non-homologous end joining at telomere  
    acts_upstream_of_or_within protection from non-homologous end joining at telomere  
    involved_in protection from non-homologous end joining at telomere  
    involved_in protein localization to chromosome, telomeric region  
    involved_in protein localization to chromosome, telomeric region  
    involved_in regulation of telomere maintenance  
    involved_in regulation of telomere maintenance via telomerase  
    involved_in regulation of telomere maintenance via telomerase  
    involved_in telomere capping  
    acts_upstream_of telomere maintenance  
    acts_upstream_of_or_within telomere maintenance  
    involved_in telomere maintenance  
    involved_in telomeric D-loop disassembly  
    involved_in telomeric D-loop disassembly  
    involved_in telomeric loop formation  
    involved_in telomeric loop formation  
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    located_in axon cytoplasm  
    is_active_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    located_in male germ cell nucleus  
    located_in nuclear body  
    located_in nuclear body  
    part_of nuclear telomere cap complex  
    located_in nucleoplasm  
    located_in nucleus  
    part_of shelterin complex  
    part_of shelterin complex  
    part_of telomere cap complex  

    General protein information

    Preferred Names
    telomeric repeat-binding factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108448.1NP_001101918.1  telomeric repeat-binding factor 2 isoform 1

      See identical proteins and their annotated locations for NP_001101918.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IYZ2, D3ZJF7
      Related
      ENSRNOP00000027695.7, ENSRNOT00000027695.8
      Conserved Domains (4) summary
      smart00717
      Location:444493
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11660
      Location:445493
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      cd00280
      Location:45244
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
      pfam16772
      Location:274314
      TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif
    2. NM_001242355.1NP_001229284.1  telomeric repeat-binding factor 2 isoform 2

      See identical proteins and their annotated locations for NP_001229284.1

      Status: PROVISIONAL

      Source sequence(s)
      HQ651915
      UniProtKB/TrEMBL
      A0A8I6A085, F6KWE7
      Related
      ENSRNOP00000083567.1, ENSRNOT00000098839.2
      Conserved Domains (2) summary
      cd00280
      Location:45244
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
      pfam16772
      Location:274313
      TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      51887221..51915756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097857.2XP_038953785.1  telomeric repeat-binding factor 2 isoform X1

      UniProtKB/TrEMBL
      B1H237
      Conserved Domains (2) summary
      cd11654
      Location:312353
      TRF2_RBM; RAP1 binding motif of telomere repeat binding factor
      cd00280
      Location:84283
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

    RNA

    1. XR_005496666.2 RNA Sequence

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