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    Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24667, updated on 27-Dec-2024

    Summary

    Official Symbol
    Ppm1bprovided by RGD
    Official Full Name
    protein phosphatase, Mg2+/Mn2+ dependent, 1Bprovided by RGD
    Primary source
    RGD:3374
    See related
    EnsemblRapid:ENSRNOG00000030667 AllianceGenome:RGD:3374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pp2c2; PP2C-beta
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including negative regulation of interferon-beta production; protein modification process; and regulation of signal transduction. Predicted to be located in membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 227.9), Thymus (RPKM 202.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ppm1b in Genome Data Viewer
    Location:
    6q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15399559..15460301, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (9646695..9707471, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (8219385..8280127)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479091 Neighboring gene prolyl endopeptidase-like Neighboring gene solute carrier family 3 member 1 Neighboring gene cilia- and flagella-associated protein 251-like Neighboring gene uncharacterized LOC100910809

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables histone H2AXS140 phosphatase activity  
    enables magnesium ion binding  
    enables manganese ion binding  
    enables myosin phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    Process Evidence Code Pubs
    involved_in N-terminal protein myristoylation  
    involved_in N-terminal protein myristoylation  
    involved_in chromatin remodeling  
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of canonical NF-kappaB signal transduction  
    involved_in negative regulation of defense response to virus  
    involved_in negative regulation of defense response to virus  
    involved_in negative regulation of defense response to virus  
    involved_in negative regulation of interferon-beta production  
    involved_in negative regulation of interferon-beta production  
    involved_in negative regulation of interferon-beta production  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in peptidyl-threonine dephosphorylation  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in protein dephosphorylation  
    involved_in protein dephosphorylation  
    involved_in regulation of canonical NF-kappaB signal transduction  
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in membrane  
    located_in membrane  
    located_in membrane  
    located_in nucleolus  
    located_in nucleolus  
    is_active_in nucleus  

    General protein information

    Preferred Names
    protein phosphatase 1B
    NP_001257548.1
    NP_001257549.1
    NP_149087.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270619.2NP_001257548.1  protein phosphatase 1B isoform 2

      See identical proteins and their annotated locations for NP_001257548.1

      Status: VALIDATED

      Source sequence(s)
      AJ271837, EV777419, JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K7Q5, A6H9I0, Q6P6W5, Q99ND8
      Related
      ENSRNOP00000099191.1, ENSRNOT00000154745.1
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    2. NM_001270620.2NP_001257549.1  protein phosphatase 1B isoform 3

      See identical proteins and their annotated locations for NP_001257549.1

      Status: VALIDATED

      Source sequence(s)
      AJ271837, EV777419, JAXUCZ010000006
      UniProtKB/TrEMBL
      A6H9H8, D3ZLY2, Q642F2
      Related
      ENSRNOP00000102147.1, ENSRNOT00000167508.1
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    3. NM_033096.3NP_149087.1  protein phosphatase 1B isoform 1

      See identical proteins and their annotated locations for NP_149087.1

      Status: VALIDATED

      Source sequence(s)
      AJ271837, EV777419, JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P35815, Q546R0, Q64046
      UniProtKB/TrEMBL
      A6H9H5, A6H9H9
      Related
      ENSRNOP00000109449.1, ENSRNOT00000151256.1
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      15399559..15460301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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