Mfn1 mitofusin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mfn1provided by RGD
Official Full Name: mitofusin 1provided by RGD
Primary source: RGD:621460
See related: EnsemblRapid:ENSRNOG00000011057 AllianceGenome:RGD:621460
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fzo1b
Summary: Enables identical protein binding activity. Involved in several processes, including regulation of mitochondrion organization; response to glucocorticoid; and response to hypoxia. Located in mitochondrial inner membrane and mitochondrial outer membrane. Biomarker of several diseases, including adult respiratory distress syndrome; dental fluorosis; kidney failure (multiple); pulmonary hypertension; and status epilepticus. Orthologous to human MFN1 (mitofusin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 587.3), Muscle (RPKM 401.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (117240525..117288017)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (115313380..115359651)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (118929738..118971689)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitofusin 1 and 2 differentially regulate mitochondrial function underlying Ca[2+] signaling and proliferation in rat aortic smooth muscle cells.
Title: Mitofusin 1 and 2 differentially regulate mitochondrial function underlying Ca(2+) signaling and proliferation in rat aortic smooth muscle cells.
The Mfn1-betaIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage.
Title: The Mfn1-βIIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage.
miR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting MFN1 and MFN2.
Title: miR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting MFN1 and MFN2.
Notch1 protects against myocardial ischaemia-reperfusion injury via regulating mitochondrial fusion and function.
Title: Notch1 protects against myocardial ischaemia-reperfusion injury via regulating mitochondrial fusion and function.
elongation of mitochondria was observed at 4 h after cardiac arrest, whereas fragmented mitochondria were significantly increased, along with concomitant increase in the fission proteins Drp1 and Fis1 and a reduction in the fusion proteins Mfn1 and Mfn2 at 12 h and 24 h after cardiac arrest
Title: Dynamic Changes of Mitochondrial Fusion and Fission in Brain Injury after Cardiac Arrest in Rats.
Hypoxia leads to upregulation of mitofusin 1 (Mfn1) both in vivo and in vitro. Mfn1 is involved in hypoxia-induced PASMCs proliferation. Mfn1-mediated mitochondrial homeostasis is regulated by miR-125a. MiR-125a plays a role in PASMCs oxidative phosphorylation and glycolysis.
Title: MiR-125a regulates mitochondrial homeostasis through targeting mitofusin 1 to control hypoxic pulmonary vascular remodeling.
results implied that HO-1 upregulation suppressed oxidative stress induced by LPS, and the possible mechanism could be associated with Mfn1 and the PI3K/Akt pathway.
Title: Effect of Heme Oxygenase-1 on Mitofusin-1 protein in LPS-induced ALI/ARDS in rats.
Studied role of plant-derived miR5338 in Mfn1 inhibition in rape bee pollen treatment for benign prostatic hyperplasia.
Title: Study on the inhibition of Mfn1 by plant-derived miR5338 mediating the treatment of BPH with rape bee pollen.
In the renal tissues of rats with chronic fluorosis, expression of both Mfn1 protein and mRNA was clearly reduced, whereas that of Fis1 was elevated.
Title: The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress.
Data identify MFN1 as an ERK target to modulate mitochondrial shape and apoptosis.
Title: Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GTP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GTP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular distribution of mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion localization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion localization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to flavonoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fluoride	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypobaric hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of outer mitochondrial membrane protein complex	IEA Inferred from Electronic Annotation more info
part_of outer mitochondrial membrane protein complex	ISO Inferred from Sequence Orthology more info
part_of outer mitochondrial membrane protein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitofusin-1

Names: mitochondrial transmembrane GTPase FZO1B; transmembrane GTPase MFN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138976.2 → NP_620432.2 mitofusin-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q8R4Z9

UniProtKB/TrEMBL

A0A0G2K5J3, A6IHP3

Related

ENSRNOP00000073448.2, ENSRNOT00000077170.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

117240525..117288017

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101679.2 → XP_038957607.1 mitofusin-1 isoform X1

UniProtKB/Swiss-Prot

Q8R4Z9

UniProtKB/TrEMBL

A0A0G2K5J3, A6IHP3

Conserved Domains (2) summary

cd09912
Location:76 → 328

DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins

pfam04799
Location:577 → 735

Fzo_mitofusin; fzo-like conserved region
XM_039101680.2 → XP_038957608.1 mitofusin-1 isoform X2

UniProtKB/Swiss-Prot

Q8R4Z9

UniProtKB/TrEMBL

D3ZR27

Related

ENSRNOP00000060265.4, ENSRNOT00000065144.5

Conserved Domains (2) summary

cd09912
Location:76 → 328

DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins

pfam04799
Location:542 → 700

Fzo_mitofusin; fzo-like conserved region
XM_039101681.2 → XP_038957609.1 mitofusin-1 isoform X3

UniProtKB/Swiss-Prot

Q8R4Z9

UniProtKB/TrEMBL

A0A8I6GGI5

Related

ENSRNOP00000087917.1, ENSRNOT00000116019.2

Conserved Domains (2) summary

pfam04799
Location:541 → 699

Fzo_mitofusin; fzo-like conserved region

cl38936
Location:76 → 292

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_063281273.1 → XP_063137343.1 mitofusin-1 isoform X3

UniProtKB/Swiss-Prot

Q8R4Z9

UniProtKB/TrEMBL

A0A8I6GGI5