Tnxb tenascin XB [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Tnxbprovided by RGD
Official Full Name: tenascin XBprovided by RGD
Primary source: RGD:1594402
See related: AllianceGenome:RGD:1594402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tnx
Summary: Predicted to enable collagen binding activity; collagen fibril binding activity; and heparin binding activity. Predicted to be involved in collagen metabolic process; elastic fiber assembly; and positive regulation of collagen fibril organization. Predicted to act upstream of or within several processes, including collagen fibril organization; regulation of JUN kinase activity; and triglyceride metabolic process. Predicted to be located in extracellular matrix; extracellular space; and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and vesicoureteral reflux. Orthologous to human TNXB (tenascin XB). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: not in current annotation release
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Genomic context

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Location:: 20p12

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Process of replication in the postnatal soft-diet rat temporomandibular joint, as measured by distribution of tenascin-X.
Title: Distribution of tenascin-C and tenascin-X, apoptotic and proliferating cells in postnatal soft-diet rat temporomandibular joint (TMJ).

Submit: New GeneRIF Correction

General gene information

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Markers

RH94616 (e-PCR)
- UniSTS:119864

BF413235 (e-PCR)
- UniSTS:248523

RH134814 (e-PCR)
- UniSTS:218092

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen fibril binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in collagen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in elastic fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen fibril organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tenascin XB

Names: tenascin X pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416371.1 → NP_001403300.1 tenascin XB precursor

Status: VALIDATED

Source sequence(s)

JACYVU010000323

UniProtKB/TrEMBL

A0A8I6AJ44

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_004620.2: Suppressed sequence

Description

NG_004620.2: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.