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    Dync2li1 dynein cytoplasmic 2 light intermediate chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298767, updated on 4-Jan-2025

    Summary

    Official Symbol
    Dync2li1provided by RGD
    Official Full Name
    dynein cytoplasmic 2 light intermediate chain 1provided by RGD
    Primary source
    RGD:1310286
    See related
    EnsemblRapid:ENSRNOG00000005151 AllianceGenome:RGD:1310286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310286
    Summary
    Enables dynein heavy chain binding activity. Predicted to be involved in intraciliary retrograde transport; intraciliary transport involved in cilium assembly; and regulation of cilium assembly. Predicted to act upstream of or within cilium assembly and determination of left/right symmetry. Predicted to be located in several cellular components, including centrosome; ciliary transition zone; and motile cilium. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in axoneme and ciliary basal body. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 141.5), Kidney (RPKM 88.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Dync2li1 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15745350..15778166, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (9992537..10025355, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (7900962..7933795)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily G member 8 Neighboring gene ATP binding cassette subfamily G member 5 Neighboring gene U6 spliceosomal RNA Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H2 Neighboring gene uncharacterized LOC134479315

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein heavy chain binding  
    enables dynein heavy chain binding  
    enables dynein heavy chain binding PubMed 
    enables dynein heavy chain binding  
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    located_in apical part of cell  
    located_in apical part of cell  
    is_active_in axoneme  
    located_in axoneme  
    located_in axoneme  
    located_in centrosome  
    located_in centrosome  
    located_in centrosome  
    is_active_in ciliary basal body  
    located_in ciliary basal body  
    located_in ciliary basal body  
    located_in ciliary basal body  
    located_in ciliary transition zone  
    located_in ciliary transition zone  
    located_in ciliary transition zone  
    located_in cilium  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    part_of cytoplasmic dynein complex  
    part_of cytoplasmic dynein complex  
    part_of cytoplasmic dynein complex  
    part_of cytoplasmic dynein complex  
    located_in cytosol  
    located_in cytosol  
    located_in microtubule  
    located_in motile cilium  
    located_in motile cilium  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    cytoplasmic dynein 2 light intermediate chain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395083.1NP_001382012.1  cytoplasmic dynein 2 light intermediate chain 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q6AY43
      UniProtKB/TrEMBL
      A0A8I5ZPI1
      Related
      ENSRNOP00000006953.4, ENSRNOT00000006953.8
      Conserved Domains (1) summary
      pfam05783
      Location:2268
      DLIC; Dynein light intermediate chain (DLIC)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      15745350..15778166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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