Il1rapl1 interleukin 1 receptor accessory protein-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il1rapl1provided by RGD
Official Full Name: interleukin 1 receptor accessory protein-like 1provided by RGD
Primary source: RGD:727891
See related: EnsemblRapid:ENSRNOG00000029663 AllianceGenome:RGD:727891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Il1rapl
Summary: Predicted to enable signaling receptor binding activity. Involved in negative regulation of exocytosis and regulation of neuron projection development. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 88.7) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (55322779..56827486, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (51371969..52876726, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (55439388..57004865, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

interaction of IL1RAPL1 with PSD-95 discloses a novel pathophysiological mechanism of cognitive impairment associated with alterations of the JNK pathway leading to a mislocalization of PSD-95 and abnormal synaptic organization and function
Title: A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation.
IL1RAPL1-related mental retardation could result from a disruption of N-type voltage-gated calcium channels and/or neuronal calcium sensor-1-dependent synaptic and neuronal activities
Title: IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation.

Submit: New GeneRIF Correction

General gene information

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Markers

BF390962 (e-PCR)
- UniSTS:249621

AU024941 (e-PCR)
- UniSTS:115751

DXGot60 (e-PCR)
- UniSTS:114505

DXRat29 (e-PCR), detects polymorphism
- UniSTS:119628

IL1RAPL1_153 (e-PCR)
- UniSTS:277370

RH143953 (e-PCR)
- UniSTS:233199

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
NOT enables interleukin-1 binding	ISO Inferred from Sequence Orthology more info
NOT enables interleukin-1 binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of exocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in presynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by trans-synaptic complex	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by trans-synaptic complex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-1 receptor accessory protein-like 1

Names: IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1

XP_017457576.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177935.3 → NP_808796.2 interleukin-1 receptor accessory protein-like 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P59824

UniProtKB/TrEMBL

A0A096MJW6, A6IPX4

Related

ENSRNOP00000068289.2, ENSRNOT00000076283.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

55322779..56827486 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017602087.3 → XP_017457576.1 interleukin-1 receptor accessory protein-like 1 isoform X1

Conserved Domains (5) summary

cd05896
Location:32 → 135

Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)

PHA02785
Location:9 → 334

PHA02785; IL-beta-binding protein; Provisional

smart00408
Location:260 → 341

IGc2; Immunoglobulin C-2 Type

pfam01582
Location:405 → 559

TIR; TIR domain

cl11960
Location:148 → 234

Ig; Immunoglobulin domain