Bmpr1b bone morphogenetic protein receptor type 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmpr1bprovided by RGD
Official Full Name: bone morphogenetic protein receptor type 1Bprovided by RGD
Primary source: RGD:1595863
See related: EnsemblRapid:ENSRNOG00000016289 AllianceGenome:RGD:1595863
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CFK-43a
Summary: Predicted to enable several functions, including ATP binding activity; BMP binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including BMP signaling pathway; ovarian cumulus expansion; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within several processes, including cartilage development; neuron differentiation; and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in acromesomelic dysplasia-3; brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 67.5), Brain (RPKM 36.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (233211525..233544344, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (230538252..230871077, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (247392195..247662026, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The upregulation in BMP/BMPR expression after nerve transection suggests that they may play a role in the healing response of the peripheral nerve.
Title: Are BMPs involved in normal nerve and following transection?: a pilot study.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_8975-8976:1025019065:3 (e-PCR)
- UniSTS:531260

AI385617 (e-PCR)
- UniSTS:159196

Z23143 (e-PCR)
- UniSTS:125921

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables BMP receptor activity	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables activin receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables activin receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor activity, type I	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type III	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage condensation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in dorsal/ventral pattern formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eye development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in ovarian cumulus expansion	ISO Inferred from Sequence Orthology more info
involved_in ovulation cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal ganglion cell axon guidance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein receptor type-1B

Names: bone morphogenetic protein binding serine/threonine kinase receptor; bone morphogenetic protein receptor, type IB

NP_001019430.2

EC 2.7.11.30

XP_006233462.1

EC 2.7.11.30

XP_006233463.1

EC 2.7.11.30

XP_017446432.1

EC 2.7.11.30

XP_038958406.1

EC 2.7.11.30

XP_038958408.1

EC 2.7.11.30

XP_038958409.1

EC 2.7.11.30

XP_038958410.1

EC 2.7.11.30

XP_063138049.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024259.4 → NP_001019430.2 bone morphogenetic protein receptor type-1B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5ZJI2, A0A8I5ZXN2, A6HW56

Related

ENSRNOP00000021963.8, ENSRNOT00000021963.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

233211525..233544344 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102481.2 → XP_038958409.1 bone morphogenetic protein receptor type-1B isoform X2

UniProtKB/TrEMBL

A0A8I5ZJI2, A0A8I5ZXN2, A6HW56

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_039102480.2 → XP_038958408.1 bone morphogenetic protein receptor type-1B isoform X2

UniProtKB/TrEMBL

A0A8I5ZJI2, A0A8I5ZXN2, A6HW56

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_006233400.5 → XP_006233462.1 bone morphogenetic protein receptor type-1B isoform X2

See identical proteins and their annotated locations for XP_006233462.1

UniProtKB/TrEMBL

A0A8I5ZJI2, A0A8I5ZXN2, A6HW56

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_039102478.2 → XP_038958406.1 bone morphogenetic protein receptor type-1B isoform X2

UniProtKB/TrEMBL

A0A8I5ZJI2, A0A8I5ZXN2, A6HW56

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_063281979.1 → XP_063138049.1 bone morphogenetic protein receptor type-1B isoform X1

UniProtKB/TrEMBL

A0A8I5ZXN2, A0A8I6A0G0

Related

ENSRNOP00000086028.1, ENSRNOT00000114929.2
XM_006233401.5 → XP_006233463.1 bone morphogenetic protein receptor type-1B isoform X2

See identical proteins and their annotated locations for XP_006233463.1

UniProtKB/TrEMBL

A0A8I5ZJI2, A0A8I5ZXN2, A6HW56

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_039102482.2 → XP_038958410.1 bone morphogenetic protein receptor type-1B isoform X2

UniProtKB/TrEMBL

A0A8I5ZJI2, A0A8I5ZXN2, A6HW56

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_017590943.3 → XP_017446432.1 bone morphogenetic protein receptor type-1B isoform X3

UniProtKB/TrEMBL

A0A8I5ZXN2, M0R3J4

Related

ENSRNOP00000077524.2, ENSRNOT00000109499.2